Sep 01, 2018
Yu RAO publishes"Synthesis, Evaluation, and Structure-Activity Relationship Study of Lanosterol Derivatives" in Journal of Medicinal Chemistry
We describe here the development of potent synthetic analogues of naturally occurring triterpenoid lanosterol to reverse protein aggregation in cataracts. Lanosterol showed superiority to other scaffolds in terms of efficacy and generality in previous studies. Various modified lanosterol derivatives were synthesized via modification of the side chain, ring A, ring B and ring C. Evaluation of th...