The choroid supplies nutrition and oxygen for the retinal pigment epithelial cells, the outer five layers of the retina, especially in the macular fovea. Choroidal capillary atrophy is a significant pathological change found in many blinding eye diseases such as age-related macular degeneration, retinitis pigmentosa, myopic maculopathy, etc. However, currently there is no effective treatment. ...

Mammalian oocyte maturation is a special biological process in which gene transcription is arrested, and mainly regulated by gene translation. At present, most of the omics studies on oocyte maturation are based on the transcriptional expression level, which cannot accurately reflect the translational expression level of genes. Moreover, profiling of translatome requires a large number of cells...

Hematopoietic stem cells (HSC) reside in the bone marrow and possess the ability to self-renewal and differentiate into all blood cell types; therefore hold great potential in cell-based therapies and regenerative medicine. In 2019, Zeng et al. reported the single-cell map of hematopoietic stem cells (HSCs) generated in the human embryo (Zeng et al., 2019). However, due to the inaccessibility o...

Breast cancer is one of the leading causes of cancer-related mortality in women.Immunotherapy, especially immune checkpoint inhibitors (ICIs), including PD-1, PD-L1 and CTLA-4 blocking antibodies, has generated remarkable responses in many individuals with solid tumors. However, in breast cancer, especially triple-negative breast cancer (TNBC), limited patients benefit from ICI therapy, indicat...

Prof. Jing-Ren Zhang’s group at Center for Infectious Disease Research, School of Medicine, Tsinghua University published research article on March 9, 2022 in Journal of Experimental Medicine entitled “Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria”. This work demonstrated how the capsules enable bacterial pathogens to circumvent molecula...

Editor’s noteEarly diagnosis can make a world of difference for cancer patients. This is particularly true for patients with lung cancer as the disease is usually diagnosed in a late stage when it might be already too late.To improve the early diagnosis and treatment of lung cancer, Tsinghua’s Professor Peng Liu and his team have come up with a new drug sensitivity testing system that can pro...

Collaborative research carried out by researchers from the School of Medicine, Tsinghua University, and Cambridge University, United Kingdom, set up machine learning-assisted high-content image analysis to study pluripotent stem cell-derived embryos in vitro. The study enabled automated and high-throughput analysis of stem cell-based embryo models. Stem cell-based embryo models synthesized b...

Collaborative research carried out by researchers from the School of Medicine, Tsinghua University, and Cambridge University, United Kingdom, set up machine learning-assisted high-content image analysis to study pluripotent stem cell-derived embryos in vitro. The study enabled automated and high-throughput analysis of stem cell-based embryo models. Stem cell-based embryo models synthesized b...

A team of researchers from Tsinghua’s School of Pharmaceutical Sciences and the School of Medicine have developed a convenient and highly sensitive home-testing device for COVID-19 (BINAS),&nbsp...

Dr. Jie Na’s group generated a MESP1 cardiovascular progenitor reporter cell line to facilitate highly efficient cardiomyocyte, endothelial cells and vascular smooth muscle cells differentiation and heart repair