微生物与传染病学

王雅婷

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Tel: +86-10-62799141
E-mail: yatingwang at tsinghua.edu.cn
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2008年本科毕业于南开大学生物技术专业，2014年获得芝加哥大学博士学位（导师是Olaf Schneewind教授和何川教授）。2015年以博士后身份加入美国圣路易斯华盛顿大学从事感染免疫的研究工作（合作导师是Herbert“Skip”Virgin教授和Christina Stallings教授）。2021年加入清华大学医学院任助理教授研究员，课题组负责人。

我们研究方向是病原体和免疫系统之间的相互作用。病原微生物感染是对人类健康的持续威胁。 我们中的大多数人都没有意识到这一威胁，因为我们的免疫系统的出色工作：在感染性微生物引起症状之前将其消灭。 我们实验室的兴趣在于了解免疫系统如何抵抗病原微生物。 我们利用现代分子生物学、生物化学、遗传学、细胞生物学并结合动物模型等方法来剖析介导宿主防御感染的基本机制。我们同时也对病原体逃避宿主免疫攻击并引起疾病的机制感兴趣。课题组的长期目标是找到广谱抗感染的机制，进而研发疫苗和抗感染药物。目前我们感兴趣的病原微生物包括：结核杆菌，金黄葡萄球菌，李斯特菌，流感病毒，疱疹病毒等；我们感兴趣的广谱抗感染通路是自噬通路。

1. Feng S, McNehlan ME, Kinsella RL, Chowdhury CS, Chavez SM, Naik SK, McKee SR, Van Winkle JA, Dubey N, Samuels A, Swain A, Cui X, Hendrix SV, Woodson R, Kreamalmeyer D, Smirnov A, Artyomov MN, Virgin HW, Wang YT#, Stallings CL#. Autophagy Promotes Efficient T Cell Responses to Restrict High-Dose Mycobacterium Tuberculosis Infection in Mice. Nature Microbiol. 2024

2. Wang YT, Sansone A, Smirnov A, Stallings CL, Orvedahl A. Myeloid autophagy genes protect mice against fatal TNF- and LPS-induced cytokine storm syndromes, Autophagy, 2023 19:4, 1114-1127.

3. Balce DR,Wang YT, McAllaster MR, Dunlap BF., Orvedahl A, Hykes B, Droit L, Handley SA, Wilen CB, Doench JG, Orchard RC, Stallings SL, Virgin HW. UFMylation inhibits the pro-inflammatory capacity of interferon-γ-activated macrophages. Proc Natl Acad Sci USA. 2021 Jan 5;118(1):e2011763118.

4.Wang YT#, Zaitsev K, Lu Q, Li S, Schaiff WT, Kim KW, Droit L, Wilen CB, Desai C, Balce DR, Orchard RC, Orvedahl A, Park S, Kreamalmeyer D, Handley SA, Pfeifer JD, Baldridge MT, Artyomov MN, Stallings CL#, Virgin HW#. Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes. Nat Microbiol. 2020 Feb;5(2):272-281. #corresponding author.

5. Orvedahl A, McAllaster MR, Dunlap B, Sansone A, Desai C,Wang YT,Balce DR, Luke CJ, Lee S, Orchard RC, Artyomov MN, Handley SA, Doench JG, Silverman GA, Virgin HW. Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock. Proc Natl Acad Sci USA. 2019 Aug13;116(33):16497-16506.

6. Wilen CB, Lee S, Hsieh LL, Orchard RC, Desai C, Hykes BL Jr, McAllaster MR, Balce DR, Feehley T, Brestoff JR, Hickey CA, Yokoyama CC,Wang YT,MacDuff DA, Kreamalmayer D, Howitt MR, Neil JA, Cadwell K, Allen PM, Handley SA, van Lookeren Campagne M, Baldridge MT, Virgin HW. Tropism for tuft cells determines immune promotion of norovirus pathogenesis. Science. 2018 Apr 13;360(6385):204-208.

7. Kim KW, Williams JW,Wang YT,Ivanov S, Gilfillan S, Colonna M, Virgin HW, Gautier EL, Randolph GJ. MHC II+ resident peritoneal and pleural macrophages rely on IRF4 for development from circulating monocytes. J Exp Med. 2016 Sep 19;213(10):1951-9.

8. Zhang J, Liu H, Zhu K, Gong S, Dramsi S,Wang YT,Li J, Chen F, Zhang R, Zhou L, Lan L, Jiang H, Schneewind O, Luo C, Yang CG. Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase. Proc Natl Acad Sci USA. 2014 Sep 16;111(37):13517-22.

9.Wang YT,Missiakas D, Schneewind O. GneZ, a UDP-GlcNAc 2-epimerase, is required for S-layer assembly and vegetative growth of Bacillus anthracis. J Bacteriol. 2014 Aug 15;196(16):2969-78.

10. Deng FK, Zhang L,Wang YT,Schneewind O, Kent SB. Total chemical synthesis of the enzyme sortase A(ΔN59) with full catalytic activity. Angew Chem Int Ed Engl. 2014 Apr 25;53(18):4662-6.

11. Lunderberg JM, Nguyen-Mau SM, Richter GS,Wang YT,Dworkin J, Missiakas DM, Schneewind O. Bacillus anthracis acetyltransferases PatA1 and PatA2 modify the secondary cell wall polysaccharide and affect the assembly of S-layer proteins. J Bacteriol. 2013 Mar;195(5):977-89.

12.Wang YT, Oh SY, Hendrickx AP, Lunderberg JM, Schneewind O. Bacillus cereus G9241 S-layer assembly contributes to the pathogenesis of anthrax-like disease in mice. J Bacteriol. 2013 Feb;195(3):596-605.

13. Garufi G*,Wang YT*, Oh SY, Maier H, Missiakas DM, Schneewind O. Sortase-conjugation generates a capsule vaccine that protects guinea pigs against Bacillus anthracis. Vaccine. 2012 May 14;30(23):3435-44. *co-first author.