Precision medicine, as one of the important special projects of research on health security development during the 13th Five-Year Plan, is closely related to the national strategic transformation and the construction of the “big health” system. The Institute of Precision Medicine of Tsinghua University was established in January 2016. It is a requirement of the times for the development of medical science and technology. It is one of the important paths for the rapid rise of Tsinghua University's medical career. It is a measure to respond to the country's strategic needs for deepening medical reform. The Institute of Precision Medicine will promote the transformation of scientific and technological achievements of Tsinghua University, increase the international influence of my country's precision medicine, and make outstanding contributions to promoting the sustainable development of precision medicine.