PI时期代表性论文 (#代表通讯作者)
Zhao J, Li X, Li X, Ren P, Wu Y, Gong H, Wu L, Huang J, Wang S, Guo Z, Chen M#, Zeng Z# and Pan D#. Targeting plasticity in the pyrimidine synthesis pathway potentiates macrophage-mediated phagocytosis in pancreatic cancer models. J Clin Invest., 2025 Nov 17;135(22):e193370. doi: 10.1172/JCI193370.
Wang H, Zhao F, Li Y, Wang P, Wang Y, Ren P, Li C, Zheng H, Zeng Z#, and Pan D#. ZNF296 Drives Immune Evasion in Epithelial Cancers by Repressing Immune Stimulatory Genes. Cancer Res., 2025 Sep 24. doi: 10.1158/0008-5472.CAN-25-0153.
Lu Y, Luo C, Huang L, Wu G, Zhong L, Chu J, Wang F#, Zeng Z# and Pan D#. Functional genetic screens reveal key pathways instructing the molecular phenotypes of tumor-associated macrophages. Cancer Immunol Res., 2025 Sep 4. doi: 10.1158/2326-6066.CIR-25-0488.
Tang K, Wu L#, Hu Y, Xue T, Jin Y, Zhou X, Luo C, Zhao Y, Tong L, Dai J, Feng D, Zeng Z# and Pan D#. Perturbation of Calreticulin potentiates CD8+ T cell-mediated anti-tumor immunity. Journal of Experimental Medicine, 2025 Oct 6;222(10):e20242360. doi: 10.1084/jem.20242360.
Zhou X, Xu T, Li C, He Y, Hu Y, Gong H, Li J, Jiang H, Wen L, Fu Y, Zeng Z#, Pan D#. Potentiating anti-tumor immunity by re-engaging immune synapse molecules. Cell Reports Medicine, Feb 14:101975. doi: 10.1016/j.xcrm.2025.101975.
Luo C, Zhang R, Guo R, Wu L, Xue T, He Y, Jin Y, Zhao Y, Zhang Z, Zhang P, Ye S, Li X, Li D, Zhang W, Wang C, Lai L, Pan-Hammarström Q, Wucherpfennig KW, Gao Z#, Pan D#, Zeng Z# Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells. Immunity, 2025 Mar 11;58(3):745-765.e9. doi: 10.1016/j.immuni.2025.02.007.
Wu L, Jin Y, Zhao X, Tang K, Zhao Y, Tong L, Yu X, Xiong K, Luo C, Zhu J, Wang F#, Zeng Z#, Pan D#. Tumor aerobic glycolysis confers immune evasion through modulating sensitivity to T cell-mediated bystander killing via TNFa. Cell Metabolism, 2023 Sep 5;35(9):1580-1596.e9. doi: 10.1016/j.cmet.2023.07.001.
博士后和学生时期代表性论文
Ito Y*, Pan D*, Zhang W, Zhang X, Juan TY, Pyrdol JW, Kyrysyuk O, Doench JG, Liu XS, Wucherpfennig KW. Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer Cells to T cell-Secreted Cytokines. Cancer Discovery 2023 May 4;13(5):1186-1209. doi: 10.1158/2159-8290.CD-22-1125. (* Denotes equal contribution)
Pan D*, Kobayashi A*, Jiang P*, Andrade LF, Tay RE, Luoma A, Tsoucas D, Qiu X, Lim K, Rao P, Long HW, Yuan G, Doench J, Brown M, Liu XL, and Wucherpfennig KW. A Major Chromatin Regulator Determines Resistance of Tumor cells to T cell Mediated Killing. Science, 2018 Jan 4; pii:eaao1710 doi: 10.1126/science.aao1710. (* Denotes equal contribution)
Jiang P*, Gu S*, Pan D*, Fu J, Li Z, Bu X, Li B, Liu JS, Freeman G, Brown M, Wucherpfennig KW and Liu XL. Signatures of T-cell dysfunction and exclusion predict cancer immunotherapy response. Nature Medicine, 2018 Oct;24(10):1550-1558. (* Denotes equal contribution)
Pan D, Jiang C, Ma Z, Blonska M, You MJ and Lin X. The role of MALT1 in EGFR induced NF-kappaB activation and EGFR associated lung cancer progression. Oncogene. 2016 Feb 18; 35(7):919-28.
Pan D*, Zhu Y*, Zhou Z, Wang T, You H, Jiang C and Lin X. CARMA3-BCL10-MALT1 -mediated NF-kB activation contributes to HRE2-assocaited tumor malignancy in breast cancer. Molecular Cancer Research 2016 Jan ;14(1):93-102. (* denotes equal contribution)
