蛋白泛素化在免疫系统的调控机制。蛋白泛素化是一种重要的蛋白质翻译后修饰过程，参与‌细胞周期、‌增殖、‌凋亡、分化、信号传递和损伤修复等多种生命活动。泛素化过程的失调可能导致蛋白质的异常降解或积累，进而引发多种疾病的发生和发展。本实验室主要通过免疫学实验手段，结合细胞生物学、分子生物学和多组学等技术，着重于Th2细胞、调节性T细胞、及二型天然淋巴细胞等多种免疫细胞发育和功能研究，免疫细胞的代谢调控，以及免疫相关疾病（如过敏性疾病和自身免疫病）的发生和发展机制。

发现VHL、Itch和c-Cbl等多种泛素酶调控免疫细胞分化和功能，参与炎症性疾病发生和发展的机制。迄今为止在国际权威学术杂志包括Science、Immunity、Nature Immunology等发表论文100余篇，累计影响因子超过800，被引用次数多达13000余次, H指数57。自2009年至今担任Molecular and Cellular Biology 杂志编辑，Frontier in Immunology，T Cell Biology 杂志副编辑。曾任Journal of Immunology 杂志编辑 (2009-2013)，和 NIH Cellular and Molecular Immunology-A study section 评委 (2010-2014)。

2019-2023年连续五年入选爱思唯尔（ELSEVIER）中国高被引学者榜单

1.Hypoxia induces adrenomedullin from lung epithelia, stimulating ILC2 inflammation and immunity. Han J, Wan Q, Seo GY, Kim K, El Baghdady S, Lee JH, Kronenberg M, Liu YC*. J Exp Med. 2022 Jun 6;219(6).

2.The E3 ligase VHL promotes follicular helper T cell differentiation via glycolytic-epigenetic control. Zhu Y, Zhao Y, Zou L, Zhang D, Aki D, Liu YC*. J Exp Med. 2019 Jul 1;216(7):1664-1681.

3.The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation. Zhang W, Li Q, Li D, Li J, Aki D, Liu YC*. J Exp Med. 2018 Dec 3;215(12):3180-3193.

4.The E3 ligases Itch and WWP2 cooperate to limit TH2 differentiation by enhancing signaling through the TCR. Aki D#, Li H#, Zhang W#, Zheng M, Elly C, Lee JH, Zou W, Liu YC*. Nat Immunol. 2018 Jul;19(7):766-775.

5.E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor. Li Q#, Li D#, Zhang X#, Wan Q, Zhang W, Zheng M, Zou L, Elly C, Lee JH, Liu YC*. Immunity. 2018 Feb 20;48(2):258-270.e5.

6.SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex. Park Y, Jin HS, Lopez J, Lee J, Liao L, Elly C, Liu YC*. Nat Immunol. 2016 Mar;17(3):286-96.

7.E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1α to Maintain Regulatory T Cell Stability and Suppressive Capacity. Lee JH, Elly C, Park Y, Liu YC*. Immunity. 2015 Jun 16;42(6):1062-74.

8.The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells. Xiao N, Eto D, Elly C, Peng G, Crotty S, Liu YC*. Nat Immunol. 2014 Jul;15(7):657-66.

9.K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signaling. Huang H, Jeon MS, Liao L, Yang C, Elly C, Yates JR 3rd, Liu YC*. Immunity. 2010 Jul 23;33(1):60-70.

10.The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Joazeiro CA, Wing SS, Huang H, Leverson JD, Hunter T, Liu YC. Science. 1999 Oct 8;286(5438):309-12.