研究领域

二型天然淋巴细胞和自然杀伤性T细胞的发育和功能研究。

科学贡献

发现E3泛素连接酶VHL通过降解缺氧诱导因子HIF1a调控二型天然淋巴细胞的发育和功能，影响过敏性哮喘的发生发展。

1.Wen Zhang; Qian Li; Dulei Li; Jia Li; Daisuke Aki; Yun-Cai Liu*; The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation, J Exp Med, 2018, 215(12): 3180-3193.

2.Daisuke Aki; Qian Li; Hui Li; Yun-Cai Liu*; Jee Ho Lee*; Immune regulation by protein ubiquitination: roles of the E3 ligases VHL and Itch, Protein Cell, 2018, 10(6): 395-404.

3.Qian Li#; Dulei Li#; Xian Zhang#; Qingqing Wan; Wen Zhang; Mingke Zheng; Le Zou; Chris Elly; Jee H Lee; Yun-Cai Liu*; E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor, Immunity, 2018, 48(2): 258-270

4.Li Wang#; Qian Li#; Lianfeng Wu; Shengwu Liu; Yong Zhang; Xuan Yang; Pingping Zhu; Honglian Zhang; Kai Zhang; Jizhong Lou; Pingsheng Liu; Liang Tong*; Fei Sun*; Zusen Fan*; Identification of SERPINB1 as a physiological inhibitor of human granzyme H, J Immunol, 2013, 190(3): 1319-30