Tsinghua Medicine,Tsinghua University

Apr 29, 2017
Yefeng TANG publishes “Denitrogenative Suzuki and carbonylative Suzuki coupling reacti...

Unprecedented palladium-catalyzed denitrogenative Suzuki and carbonylative Suzuki coupling reactions of benzotriazoles with boronic acids have been realized, leading to the possibility
Apr 29, 2017
Ligong CHEN publishes “A "functional signaling indispensable is for c-Myc driven

Amplification and/or activation of the c-Myc protooncogene is one of the leading genetic events leading to hepatocarcinogenesis. The oncogenic potential of c-Myc has been proven experimentally b
May 18, 2017
Yefeng Tang research group publishes “Total Synthesis of Homodimericin A” in Angew. C...

We report the concise total synthesis of homodimericin A, a recently identified fungal metabolite bearing an unprecedented molecular architecture. The success of the approach hinges on a series
Aug 20, 2017
Xuebin LIAO research group publishes “In situ generation of N-unsubstituted imines fro...

Although azides have been widely used in nitrene transfer reactions, in situ generation of N-H imines from azides for downstream transformations has rarely been explored. We report copper-mediated
Nov 27, 2017
Bailong XIAO publishes"A protein interaction mechanism for suppressing the mechanosensi...

Piezo proteins are bona fide mammalian mechanotransduction channels for various cell types including endothelial cells. The mouse Piezo1 of 2547 residues forms a three-bladed, propeller-like
Mar 5, 2018
Gelin WANG publishes “Anti-mitotic Chemotherapeutics Promote Apoptosis through TL1A-ac...

The commonly used anti-mitotic chemotherapeutic agents such as taxol and vinblastine arrest cell cycle progression by disrupting mitotic spindles, and cause cancer cells to undergo apoptosis through
Sep 1, 2018
Yu RAO publishes"Synthesis, Evaluation, and Structure-Activity Relationship Study of La...

We describe here the development of potent synthetic analogues of naturally occurring triterpenoid lanosterol to reverse protein aggregation in cataracts. Lanosterol showed superiority to other
Sep 20, 2018
Zeping HU publishes "Arginine Deficiency Involved in Thrombocytopenia and Immunosuppres...

Severe fever with thrombocytopenia syndrome (SFTS) caused by a recently identified bunyavirus, SFTSV, is an emerging infectious disease with extensive geographical distribution and high mortality.
Jan 23, 2018
Bailong XIAO publishes"Structure and Mechanogating Mechanism of the Piezo1 Channel" in ...

The mechanosensitive Piezo channels function as key eukaryotic mechanotransducers. However, their structures and mechanogating mechanisms remain unknown. Here, we determine the three-bladed
Sep 28, 2018
Yonghui ZHANG publishes "The mevalonate pathway is a druggable target for vaccine adjuv...

Highlights Lipophilic statins and lipophilic bisphosphonates are potent vaccine adjuvants Modulation of post-translational protein prenylation confers adjuvanticity Decreased protein prenylation

Total of 844 Home Previous Next Last Total of 85 Current 15 page

Yefeng TANG publishes “Denitrogenative Suzuki and carbonylative Suzuki coupling reacti...

Unprecedented palladium-catalyzed denitrogenative Suzuki and carbonylative Suzuki coupling reactions of benzotriazoles with boronic acids have been realized, leading to the possibility

Ligong CHEN publishes “A "functional signaling indispensable is for c-Myc driven

Amplification and/or activation of the c-Myc protooncogene is one of the leading genetic events leading to hepatocarcinogenesis. The oncogenic potential of c-Myc has been proven experimentally b

Yefeng Tang research group publishes “Total Synthesis of Homodimericin A” in Angew. C...

We report the concise total synthesis of homodimericin A, a recently identified fungal metabolite bearing an unprecedented molecular architecture. The success of the approach hinges on a series

Xuebin LIAO research group publishes “In situ generation of N-unsubstituted imines fro...

Although azides have been widely used in nitrene transfer reactions, in situ generation of N-H imines from azides for downstream transformations has rarely been explored. We report copper-mediated

Bailong XIAO publishes"A protein interaction mechanism for suppressing the mechanosensi...

Piezo proteins are bona fide mammalian mechanotransduction channels for various cell types including endothelial cells. The mouse Piezo1 of 2547 residues forms a three-bladed, propeller-like

Gelin WANG publishes “Anti-mitotic Chemotherapeutics Promote Apoptosis through TL1A-ac...

The commonly used anti-mitotic chemotherapeutic agents such as taxol and vinblastine arrest cell cycle progression by disrupting mitotic spindles, and cause cancer cells to undergo apoptosis through

Yu RAO publishes"Synthesis, Evaluation, and Structure-Activity Relationship Study of La...

We describe here the development of potent synthetic analogues of naturally occurring triterpenoid lanosterol to reverse protein aggregation in cataracts. Lanosterol showed superiority to other

Zeping HU publishes "Arginine Deficiency Involved in Thrombocytopenia and Immunosuppres...

Severe fever with thrombocytopenia syndrome (SFTS) caused by a recently identified bunyavirus, SFTSV, is an emerging infectious disease with extensive geographical distribution and high mortality.

Bailong XIAO publishes"Structure and Mechanogating Mechanism of the Piezo1 Channel" in ...

The mechanosensitive Piezo channels function as key eukaryotic mechanotransducers. However, their structures and mechanogating mechanisms remain unknown. Here, we determine the three-bladed

Yonghui ZHANG publishes "The mevalonate pathway is a druggable target for vaccine adjuv...

Highlights Lipophilic statins and lipophilic bisphosphonates are potent vaccine adjuvants Modulation of post-translational protein prenylation confers adjuvanticity Decreased protein prenylation

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