研究领域

癌症发生过程与基因调控。致癌基因通过激活细胞中特定基因的转录来促进肿瘤的发生与发展。基于此，本实验室研究内容如下：1）研究癌细胞中异常激活的转录网络的起源，以及致癌基因对这些异常激活的转录网络的调控作用；2）研究肿瘤发展过程中异常激活的转录网络的变化情况，以及肿瘤抑制基因在这些异常激活的转录网络变化过程的抑制作用；3）以癌症中异常激活的基因转录网络为基础，研究肿瘤发展过程中免疫逃逸与代谢情况的变化。

科学贡献

早期利用Adeno-associated Virus (AAV)和 CRISPR/Cas9系统，成功开发出一套便捷的自发胰腺癌小鼠模型；揭示在受损伤的小鼠胰腺中，存在着一群能够促进胰腺恢复的前体细胞；阐明胰腺癌进展中Kras突变体促进转录激活的分子机制；通过这些创新性成果，以胰腺癌为模型为研究癌症发生过程的关键分子机理与基因调控提供新的理论依据与方法，鉴定与寻找治疗胰腺癌潜在的药物靶点。迄今在包括Nature、Cell在内的国际期刊上发表学术论文17篇，总引用5000次左右。

2018 国家级青年人才项目

2017 纪念斯隆凯特琳博士后研究员奖

2017 NIH K22 Award

2010 John S.Newberry Award (Columbia University)

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