荣誉奖励
2010/2011/2017 拜耳研究员奖
2014 强生研究员奖
2014 清华大学良师益友奖
代表性论文
1) He J, Yan A, Chen B, Huang J, Kee K*. 3D genome remodeling and homologous pairing during meiotic prophase of mouse oogenesis and spermatogenesis. Dev Cell. 2023 Nov 13: S1534-5807(23)00553-1. doi: 10.1016/j.devcel.2023.10.009.
2) Wang N, He J, Feng X, Liao S, Zhao Y, Tang F, Kee K*. Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8. Elife. 2023 Jan 5;12:e78421. doi: 10.7554/eLife.78421.
3) Yan A, Xiong J, Zhu J, Li X, Xu S, Feng X, Ke X, Wang Z, Chen Y, Wang HW, Zhang MQ*, Kee K*. DAZL regulates proliferation of human primordial germ cells by direct binding to precursor miRNAs and enhances DICER processing activity. Nucleic Acids Res. 2022 Oct 24:gkac856. doi: 10.1093/nar/gkac856.
4) Hu W, Zeng H, Shi Y, Zhou C, Huang J, Jia L, Xu S, Feng X, Zeng Y, Xiong T, Huang W, Sun P, Chang Y, Li T, Fang C, Wu K, Cai L, Ni W, Li Y, Yang Z, Zhang QC, Chian R, Chen Z, Liang X*, Kee K*. Single-cell transcriptome and translatome dual-omics reveals potential mechanisms of human oocyte maturation. Nat Commun. 2022 Aug 30;13(1):5114. doi: 10.1038/s41467-022-32791-2.
5) Li L, Yang R, Yin C, Kee K*. Studying human reproductive biology through single-cell analysis and in vitro differentiation of stem cells into germ cell-like cells. Hum Reprod Update. 2020 Sep 1;26(5):670-688. doi:10.1093/humupd/dmaa021.
6) Liang J, Wang N, He J, Du J, Guo Y, Li L, Wu W, Yao C, Li Z, Kee K*. Induction of Sertoli-like cells from human fibroblasts by NR5A1 and GATA4. Elife. 2019 Nov 11;8. pii: e48767. doi: 10.7554/eLife.48767.
7) Jung D, Xiong J, Ye M, Qin X, Li L, Cheng S, Luo M, Peng J, Dong J, Tang F, Shen W, Matzuk MM, Kee K*. In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells. Nat Commun.2017 Jun 12;8:15680. doi:10.1038/ncomms15680.
8) Li L, Wang B, Zhang W, Chen B, Luo M, Wang J, Wang X, Cao Y*, Kee K*. (2017). A homozygous NOBOX truncating variant causes defective transcriptional activation and leads to primary ovarian insufficiency. Hum Reprod 32(1): 248-255. doi: 10.1093/humrep/dew271.
9) Kee K, Angeles VT, Flores M, Nguyen HN, Reijo Pera RA*. (2009). Human DAZL, DAZ and BOULE genes modulate primordial germ-cell and haploid gamete formation. Nature 462(7270): 222-225. doi: 10.1038/nature08562.
10) Kee K, Protacio RU, Arora C, Keeney S*. (2004). Spatial organization and dynamics of the association of Rec102 and Rec104 with meiotic chromosomes. EMBO J 23(8): 1815-1824. doi: 10.1038/sj.emboj.7600184.
1) Li M, Jiang Z, Xu X, Wu X, Liu Y, Chen K, Liao Y, Li W, Wang X, Guo Y, Zhang B, Wen L, Kee K, Tang F. Chromatin accessibility landscape of mouse early embryos revealed by single-cell NanoATAC-seq2. Science. 2025 Mar 28;387(6741):eadp4319. Link to publications: doi: 10.1126/science.adp4319
Link to Pubmed: PMID: 40146829
2) Wen F, Ding Y, Wang M, Du J, Zhang S, Kee K*. FOXL2 and NR5A1 induce human fibroblasts into steroidogenic ovarian granulosa-like cells. Cell Prolif. 2024 Jan 8:e13589.
Link to publications: doi: 10.1111/cpr.13589
Link to Pubmed: PMID: 38192172
3) Ding Y, He Z, Sha Y, Kee K*, Li L*. Eif4enif1 haploinsufficiency disrupts oocyte
mitochondrial dynamics and leads to subfertility. Development. 2023 Dec 1;150(23):dev202151.
Link to publications: doi: 10.1242/dev.202151
Link to Pubmed: PMID: 38088064
4) He J, Yan A, Chen B, Huang J, Kee K*. 3D genome remodeling and homologous pairing during meiotic prophase of mouse oogenesis and spermatogenesis. Dev Cell. 2023 Nov 13: S1534-5807(23)00553-1.
Link to publications: doi: 10.1016/j.devcel.2023.10.009
Link to Pubmed: PMID: 37963468
5) Huang J, Chen P, Jia L, Li T, Yang X, Liang Q, Zeng Y, Liu J, Wu T, Hu W, Kee K*, Zeng H*, Liang X*, Zhou C*. Multi-Omics Analysis Reveals Translational Landscapes and Regulations in Mouse and Human Oocyte Aging. Adv Sci (Weinh). 2023 Sep;10(26):e2301538.
Link to publications: doi: 10.1002/advs.202301538
Link to Pubmed: PMID: 37401155
6) Wang N, He J, Feng X, Liao S, Zhao Y, Tang F, Kee K*. Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8. Elife. 2023 Jan 5;12:e78421.
Link to publications: doi: 10.7554/eLife.78421
Link to Pubmed: PMID: 36602025
7) Yan A, Xiong J, Zhu J, Li X, Xu S, Feng X, Ke X, Wang Z, Chen Y, Wang HW, Zhang MQ*, Kee K*. DAZL regulates proliferation of human primordial germ cells by direct binding to precursor miRNAs and enhances DICER processing activity. Nucleic Acids Res. 2022 Oct 24:gkac856.
Link to publications: doi: 10.1093/nar/gkac856
Link to Pubmed: PMID: 36273819
8) Hu W, Zeng H, Shi Y, Zhou C, Huang J, Jia L, Xu S, Feng X, Zeng Y, Xiong T, Huang W, Sun P, Chang Y, Li T, Fang C, Wu K, Cai L, Ni W, Li Y, Yang Z, Zhang QC, Chian R, Chen Z, Liang X*, Kee K*. Single-cell transcriptome and translatome dual-omics reveals potential mechanisms of human oocyte maturation. Nat Commun. 2022 Aug 30;13(1):5114.
Link to publications: doi: 10.1038/s41467-022-32791-2
Link to Pubmed: PMID: 36042231
9) Wang Y, Xie H, Chang X, Hu W, Li M, Li Y, Liu H, Cheng H, Wang S, Zhou L, Shen D, Dou S, Ma R, Mao Y, Zhu H, Zhang X, Zheng Y, Ye X, Wen L, Kee K*, Cui H*, Tang F*. Single-cell dissection of the multiomic landscape of high-grade serous ovarian cancer. Cancer Res. 2022 Aug 15:CAN-21-3819. Epub ahead of print.
Link to publications: doi: 10.1158/0008-5472.CAN-21-3819
Link to Pubmed: PMID: 35969151
10) Chen B, Zhu G, Yan A, He J, Liu Y, Li L, Yang X, Dong C, Kee K*. IGSF11 is required for pericentric heterochromatin dissociation during meiotic diplotene. PLoS Genet. 2021 Sep 7;17(9):e1009778.
Link to publications: doi: 10.1371/journal.pgen.1009778
Link to Pubmed: PMID: 34491997
11) Li L, Yang R, Yin C, Kee K*. Studying human reproductive biology through single-cell analysis and in vitro differentiation of stem cells into germ cell-like cells. Hum Reprod Update. 2020 Sep 1;26(5):670-688.
Link to publications: doi:10.1093/humupd/dmaa021
Link to Pubmed: PMID: 32464645
12) Ye M, Yang ZY, Zhang Y, Xing YX, Xie QG, Zhou JH, Wang L, Xie W, Kee K*, Chian RC*. Single-cell multiomic analysis of in vivo and in vitro matured human oocytes. Hum Reprod. 2020 Apr 28;35(4):886-900.
Link to publications: doi: 10.1093/humrep/deaa044
Link to Pubmed: PMID: 32325493
13) Liang J, Wang N, He J, Du J, Guo Y, Li L, Wu W, Yao C, Li Z, Kee K*. Induction of Sertoli-like cells from human fibroblasts by NR5A1 and GATA4. Elife. 2019 Nov 11;8. pii: e48767.
Link to publications: doi: 10.7554/eLife.48767
Link to Pubmed: PMID: 31710289
14) Wang B, Li L, Zhu Y, Zhang W, Wang X, Chen B, Li T, Pan H, Wang J, Kee K*, Cao Y*. Sequence variants of KHDRBS1 as high penetrance susceptibility risks for primary ovarian insufficiency by mis-regulating mRNA alternative splicing. Hum Reprod.2017 Oct 1;32(10):2138-2146.
Link to publications: doi: 10.1093/humrep/dex263
Link to Pubmed: PMID: 28938739
15) Jung D, Xiong J, Ye M, Qin X, Li L, Cheng S, Luo M, Peng J, Dong J, Tang F, Shen W, Matzuk MM, Kee K*. In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells. Nat Commun.2017 Jun 12;8:15680.
Link to publications: doi:10.1038/ncomms15680
Link to Pubmed: PMID: 28604658
16) Li L, Wang B, Zhang W, Chen B, Luo M, Wang J, Wang X, Cao Y*, Kee K*. (2017). A homozygous NOBOX truncating variant causes defective transcriptional activation and leads to primary ovarian insufficiency. Hum Reprod 32(1): 248-255.
Link to publications: doi: 10.1093/humrep/dew271
Link to Pubmed: PMID: 27836978
17) He Z, Kee K*. (2017). Generating a Genome Editing Nuclease for Targeted Mutagenesis in Human Cells. Methods Mol Biol 1498: 153-162.
Link to publications: doi:10.1007/978-1-4939-6472-7_10
Link to Pubmed: PMID: 27709574
18) Zhang B, Zheng H, Huang B, Li W, Xiang Y, Peng X, Ming J, Wu X, Zhang Y, Xu Q, Liu W, Kou X, Zhao Y, He W, Li C, Chen B, Li Y, Wang Q, Ma J, Yin Q, Kee K, Meng A, Gao S, Xu F, Na J*, Xie W*. (2016). Allelic reprogramming of the histone modification H3K4me3 in early mammalian development. Nature 537(7621): 553-557.
Link to publications: doi: 10.1038/nature19361
Link to Pubmed: PMID: 27626382
19) Li L, Zhou X, Wang X, Wang J, Zhang W, Wang B, Cao Y*, Kee K*. (2016). A dominant negative mutation at the ATP binding domain of AMHR2 is associated with a defective anti-Mullerian hormone signaling pathway. Mol Hum Reprod 22(9): 669-678.
Link to publications: doi:10.1093/molehr/gaw040
Link to Pubmed: PMID: 27430550
20) Lin J, Chen H, Luo L, Lai Y, Xie W, Kee K*. (2015). Creating a monomeric endonuclease TALE-I-SceI with high specificity and low genotoxicity in human cells. Nucleic Acids Res 43(2): 1112-1122.
Link to publications: doi: 10.1093/nar/gku1339
Link to Pubmed: PMID: 25541197
21) Nguyen HN, Byers B, Cord B, Shcheglovitov A, Byrne J, Gujar P, Kee K, Schüle B, Dolmetsch RE, Langston W, Palmer TD*, Pera RR*. (2011). LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress. Cell Stem Cell 8(3): 267-280.
Link to publications: doi: 10.1016/j.stem.2011.01.013
Link to Pubmed: PMID: 21362567
22) Kee K*, Flores M, Cedars MI, Reijo Pera RA*. (2010). Human primordial germ cell formation is diminished by exposure to environmental toxicants acting through the AHR signaling pathway. Toxicol Sci 117(1): 218-224.
Link to publications: doi: 10.1093/toxsci/kfq179
Link to Pubmed: PMID: 20562217
23) Kee K, Pera RA, Turek PJ*. (2010). Testicular germline stem cells. Nat Rev Urol 7(2): 94-100.
Link to publications: doi: 10.1038/nrurol.2009.263
Link to Pubmed: PMID: 20084076
24) Kee K, Angeles VT, Flores M, Nguyen HN, Reijo Pera RA*. (2009). Human DAZL, DAZ and BOULE genes modulate primordial germ-cell and haploid gamete formation. Nature 462(7270): 222-225.
Link to publications: doi: 10.1038/nature08562
Link to Pubmed: PMID: 19865085
25) Kee K, Reijo Pera RA*. (2008). Human germ cell lineage differentiation from embryonic stem cells. CSH Protoc 2008: pdb prot5048.
Link to publications: doi: 10.1101/pdb.prot5048
Link to Pubmed: PMID: 21356917
26) International Stem Cell Initiative (2007). Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat Biotechnol 25(7): 803-816.
Link to publications: doi:10.1038/nbt1318
Link to Pubmed: PMID: 17572666
27) Kee K, Gonsalves JM, Clark AT, Pera RA*. (2006). Bone morphogenetic proteins induce germ cell differentiation from human embryonic stem cells. Stem Cells Dev 15(6): 831-837.
Link to publications: doi: 10.1089/scd.2006.15.831
Link to Pubmed: PMID: 17253946
28) Henderson KA, Kee K, Maleki S, Santini PA, Keeney S*. (2006). Cyclin-dependent kinase directly regulates initiation of meiotic recombination. Cell 125(7): 1321-1332.
Link to publications: doi: 10.1016/j.cell.2006.04.039
Link to Pubmed: PMID: 16814718
29) Kee K, Protacio RU, Arora C, Keeney S*. (2004). Spatial organization and dynamics of the association of Rec102 and Rec104 with meiotic chromosomes. EMBO J 23(8): 1815-1824.
Link to publications: doi: 10.1038/sj.emboj.7600184
Link to Pubmed: PMID: 15044957
30) Arora C, Kee K, Maleki S, Keeney S*. (2004). Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism. Mol Cell 13(4): 549-559.
Link to publications: doi: 10.1016/s1097-2765(04)00063-2
Link to Pubmed: PMID: 14992724
31) Kee K, Keeney S*. (2002). Functional interactions between SPO11 and REC102 during initiation of meiotic recombination in Saccharomyces cerevisiae. Genetics 160(1): 111-122.
Link to publications: doi: 10.1093/genetics/160.1.111
Link to Pubmed: PMID: 11805049
32) Kee K, Niu L, Henderson E*. (1998). A Tetrahymena thermophila G4-DNA binding protein with dihydrolipoamide dehydrogenase activity. Biochemistry 37(12): 4224-4234.
Link to publications: doi: 10.1021/bi9716377
Link to Pubmed: PMID: 9521745
