Tsinghua Medicine,Tsinghua University

Apr 29, 2017
Ligong CHEN publishes “A "functional signaling indispensable is for c-Myc driven

Amplification and/or activation of the c-Myc protooncogene is one of the leading genetic events leading to hepatocarcinogenesis. The oncogenic potential of c-Myc has been proven experimentally b
May 18, 2017
Yefeng Tang research group publishes “Total Synthesis of Homodimericin A” in Angew. C...

We report the concise total synthesis of homodimericin A, a recently identified fungal metabolite bearing an unprecedented molecular architecture. The success of the approach hinges on a series
Aug 20, 2017
Xuebin LIAO research group publishes “In situ generation of N-unsubstituted imines fro...

Although azides have been widely used in nitrene transfer reactions, in situ generation of N-H imines from azides for downstream transformations has rarely been explored. We report copper-mediated
Nov 27, 2017
Bailong XIAO publishes"A protein interaction mechanism for suppressing the mechanosensi...

Piezo proteins are bona fide mammalian mechanotransduction channels for various cell types including endothelial cells. The mouse Piezo1 of 2547 residues forms a three-bladed, propeller-like
Jul 16, 2018
Hang YIN publishes"TLR4-dependent fibroblast activation drives persistent organ fibrosi...

Persistent fibrosis in multiple organs is the hallmark of systemic sclerosis (SSc). Recent genetic and genomic studies implicate TLRs and their damage-associated molecular pattern (DAMP) endogenous
Sep 12, 2018
Yefeng TANG and Gang LIU publish "Total Syntheses of Asperchalasines A-E" in Angew. Che...

The first total syntheses of asperchalasines A‐E, a collection of unprecedented merocytochalasans, are reported. Aspochalasin B, a key tricyclic cytochalasan monomer, was first synthesized through
Dec 13, 2017
Hang YIN publishes"Small-molecule inhibition of TLR8 through stabilization of its resti...

Endosomal Toll-like receptors (TLR3, TLR7, TLR8, and TLR9) are highly analogous sensors for various viral or bacterial RNA and DNA molecular patterns. Nonetheless, few small molecules can selectively
Jan 23, 2018
Bailong XIAO publishes"Structure and Mechanogating Mechanism of the Piezo1 Channel" in ...

The mechanosensitive Piezo channels function as key eukaryotic mechanotransducers. However, their structures and mechanogating mechanisms remain unknown. Here, we determine the three-bladed
Jan 25, 2018
Yefeng TANG publishes "Enantioselective Total Syntheses of (+)-Hippolachnin A, (+)-Grac...

The Plakortin polyketides represent a structurally and biologically fascinating class of marine natural products. Herein, we report a unified strategy that enables the divergent syntheses of various
Jun 2, 2016
Academician TU Yongqiang speaks at SPS-MSD R&D (China) seminar series

June 2nd, 2016: Dr. TU Yongqiang, Academician of the Chinese Academy of Sciences, was invited as a speaker for the“Tsinghua University School of Pharmaceutical Sciences – MSD R&D (China) Seminar

Total of 740 Home Previous Next Last Total of 74 Current 34 page

Ligong CHEN publishes “A "functional signaling indispensable is for c-Myc driven

Amplification and/or activation of the c-Myc protooncogene is one of the leading genetic events leading to hepatocarcinogenesis. The oncogenic potential of c-Myc has been proven experimentally b

Yefeng Tang research group publishes “Total Synthesis of Homodimericin A” in Angew. C...

We report the concise total synthesis of homodimericin A, a recently identified fungal metabolite bearing an unprecedented molecular architecture. The success of the approach hinges on a series

Xuebin LIAO research group publishes “In situ generation of N-unsubstituted imines fro...

Although azides have been widely used in nitrene transfer reactions, in situ generation of N-H imines from azides for downstream transformations has rarely been explored. We report copper-mediated

Bailong XIAO publishes"A protein interaction mechanism for suppressing the mechanosensi...

Piezo proteins are bona fide mammalian mechanotransduction channels for various cell types including endothelial cells. The mouse Piezo1 of 2547 residues forms a three-bladed, propeller-like

Hang YIN publishes"TLR4-dependent fibroblast activation drives persistent organ fibrosi...

Persistent fibrosis in multiple organs is the hallmark of systemic sclerosis (SSc). Recent genetic and genomic studies implicate TLRs and their damage-associated molecular pattern (DAMP) endogenous

Yefeng TANG and Gang LIU publish "Total Syntheses of Asperchalasines A-E" in Angew. Che...

The first total syntheses of asperchalasines A‐E, a collection of unprecedented merocytochalasans, are reported. Aspochalasin B, a key tricyclic cytochalasan monomer, was first synthesized through

Hang YIN publishes"Small-molecule inhibition of TLR8 through stabilization of its resti...

Endosomal Toll-like receptors (TLR3, TLR7, TLR8, and TLR9) are highly analogous sensors for various viral or bacterial RNA and DNA molecular patterns. Nonetheless, few small molecules can selectively

Bailong XIAO publishes"Structure and Mechanogating Mechanism of the Piezo1 Channel" in ...

The mechanosensitive Piezo channels function as key eukaryotic mechanotransducers. However, their structures and mechanogating mechanisms remain unknown. Here, we determine the three-bladed

Yefeng TANG publishes "Enantioselective Total Syntheses of (+)-Hippolachnin A, (+)-Grac...

The Plakortin polyketides represent a structurally and biologically fascinating class of marine natural products. Herein, we report a unified strategy that enables the divergent syntheses of various

Academician TU Yongqiang speaks at SPS-MSD R&D (China) seminar series

June 2nd, 2016: Dr. TU Yongqiang, Academician of the Chinese Academy of Sciences, was invited as a speaker for the“Tsinghua University School of Pharmaceutical Sciences – MSD R&D (China) Seminar

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