School of Pharmaceutical Sciences-Tsinghua Medicine,Tsinghua University

School of Pharmaceutical Sciences

News

Teaching News

School of Basic Medical Sciences School of Biomedical Engineering School of Pharmaceutical Sciences School of Clinical Medicine

Research Updates

Medical Updates
Notices and Announcements

School of Pharmaceutical Sciences

School of Clinical Medicine
Upcoming Events

School of Pharmaceutical Sciences

Home / News & Events / News / Research Updates

Sep 19, 2017
Ligong CHEN publishes"A Network Integration Approach for Drug-Target Interaction Prediction and Computational Drug Repositioning from Heterogeneous Information

The emergence of large-scale genomic, chemical and pharmacological data provides new opportunities for drug discovery and repositioning. In this work, we develop a computational pipeline, called DTINe...
Sep 05, 2017
Ligong CHEN publishes"Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity" in Archives of Toxicology

Zoledronate is a bisphosphonate that is widely used in the treatment of metabolic bone diseases. However, zoledronate induces significant nephrotoxicity associated with acute tubular necrosis and rena...
Aug 20, 2017
Xuebin LIAO research group publishes “In situ generation of N-unsubstituted imines from alkyl azides & applications for imine transfer” in Science Advances

Although azides have been widely used in nitrene transfer reactions, in situ generation of N-H imines from azides for downstream transformations has rarely been explored. We report copper-mediated for...
Jun 30, 2017
Liansuo Zu research group publishes “ Catalytic Enantioselective Aza-pinacol Rearrangement” in Angew. Chem. Int. Ed.

The first catalytic enantioselective asymmetric aza-pinacol rearrangement is reported. The reactions are catalyzed by a chiral phosphoric acid and proceed via a highly organized transition state invol...
May 18, 2017
Yefeng Tang research group publishes “Total Synthesis of Homodimericin A” in Angew. Chem. Int. Ed.

We report the concise total synthesis of homodimericin A, a recently identified fungal metabolite bearing an unprecedented molecular architecture. The success of the approach hinges on a series of ra...
Apr 29, 2017
Ligong CHEN research group discovers the mechanism process of renal toxicity induced by adefovir and tenofovir

Despite the therapeutic success of tenofovir (TFV) for treatment of HIV-1 infection, numerous cases of nephrotoxicity have been reported. Mitochondrial toxicity has been purported as the major target ...
Apr 29, 2017
Ligong CHEN publishes “A "functional signaling indispensable is for c-Myc driven hepatocarcinogenesis" in Hepatology

Amplification and/or activation of the c-Myc protooncogene is one of the leading genetic events leading to hepatocarcinogenesis. The oncogenic potential of c-Myc has been proven experimentally by the ...
Apr 29, 2017
Yefeng TANG publishes “Denitrogenative Suzuki and carbonylative Suzuki coupling reactions of benzotriazoles with boronic acids” in Chemical Science

Unprecedented palladium-catalyzed denitrogenative Suzuki and carbonylative Suzuki coupling reactions of benzotriazoles with boronic acids have been realized, leading to the possibility of structurally...
Apr 29, 2017
Gang LIU research group releases first report on NOD2 targeted tumor treatment

A noncleavable paclitaxel (PTX) and N-acetylmuramyl-l-alanyl-d-isoglutamine (MDP) derivative conjugate, 22 (DY-16-43), and its analogues were prepared and characterized as antagonists of NOD2 signalin...
Feb 20, 2017
Yu RAO publishes "Target Elucidation by Co-crystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium Falciparum" in Journal of Medicinal Chemistry

Drug-resistant malarial strains have been continuously emerging recently, which posts a great challenge for the global health. Therefore, new anti-malarial drugs with novel targeting mechanisms are ur...

FirstPrevious1234NextLast

News & Events

School of Pharmaceutical Sciences

News

Teaching News

Research Updates

Medical Updates

Notices and Announcements

School of Pharmaceutical Sciences

School of Clinical Medicine

Upcoming Events

News

Notices and Announcements

Upcoming Events

School of Pharmaceutical Sciences

Ligong CHEN publishes"A Network Integration Approach for Drug-Target Interaction Prediction and Computational Drug Repositioning from Heterogeneous Information

The emergence of large-scale genomic, chemical and pharmacological data provides new opportunities for drug discovery and repositioning. In this work, we develop a computational pipeline, called DTINe...

Ligong CHEN publishes"Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity" in Archives of Toxicology

Zoledronate is a bisphosphonate that is widely used in the treatment of metabolic bone diseases. However, zoledronate induces significant nephrotoxicity associated with acute tubular necrosis and rena...

Xuebin LIAO research group publishes “In situ generation of N-unsubstituted imines from alkyl azides & applications for imine transfer” in Science Advances

Although azides have been widely used in nitrene transfer reactions, in situ generation of N-H imines from azides for downstream transformations has rarely been explored. We report copper-mediated for...

Liansuo Zu research group publishes “ Catalytic Enantioselective Aza-pinacol Rearrangement” in Angew. Chem. Int. Ed.

The first catalytic enantioselective asymmetric aza-pinacol rearrangement is reported. The reactions are catalyzed by a chiral phosphoric acid and proceed via a highly organized transition state invol...

Yefeng Tang research group publishes “Total Synthesis of Homodimericin A” in Angew. Chem. Int. Ed.

We report the concise total synthesis of homodimericin A, a recently identified fungal metabolite bearing an unprecedented molecular architecture. The success of the approach hinges on a series of ra...

Ligong CHEN research group discovers the mechanism process of renal toxicity induced by adefovir and tenofovir

Despite the therapeutic success of tenofovir (TFV) for treatment of HIV-1 infection, numerous cases of nephrotoxicity have been reported. Mitochondrial toxicity has been purported as the major target ...

Ligong CHEN publishes “A "functional signaling indispensable is for c-Myc driven hepatocarcinogenesis" in Hepatology

Amplification and/or activation of the c-Myc protooncogene is one of the leading genetic events leading to hepatocarcinogenesis. The oncogenic potential of c-Myc has been proven experimentally by the ...

Yefeng TANG publishes “Denitrogenative Suzuki and carbonylative Suzuki coupling reactions of benzotriazoles with boronic acids” in Chemical Science

Unprecedented palladium-catalyzed denitrogenative Suzuki and carbonylative Suzuki coupling reactions of benzotriazoles with boronic acids have been realized, leading to the possibility of structurally...

Gang LIU research group releases first report on NOD2 targeted tumor treatment

A noncleavable paclitaxel (PTX) and N-acetylmuramyl-l-alanyl-d-isoglutamine (MDP) derivative conjugate, 22 (DY-16-43), and its analogues were prepared and characterized as antagonists of NOD2 signalin...

Yu RAO publishes "Target Elucidation by Co-crystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium Falciparum" in Journal of Medicinal Chemistry

Drug-resistant malarial strains have been continuously emerging recently, which posts a great challenge for the global health. Therefore, new anti-malarial drugs with novel targeting mechanisms are ur...

About TM

Health Care

Education

Research

News & Events