Targeting WEE1 in tumor-associated dendritic cells potentiates antitumor immunity via the cGAS/STING pathway|A/Prof. Haidong Tang

Structural insight into the self-activation and G-protein coupling of P2Y2 receptor|A/Prof. Xiangyu Liu

Structure and transport mechanism of human riboflavin transporters|Prof. Ligong Chen

Transporters in vitamin uptake and cellular metabolism: impacts on health and disease|Prof. Ligong Chen

SIRT6 Ameliorates Cancer Cachexia–Associated Adipose Wasting by Suppressing TNFR2 Signalling in Mice School of Pharmaceutical Sciences| Dr. Zhao Wang

Discovery of a Novel CRBN-Recruiting cGAS PROTAC Degrader for the Treatment of Ulcerative Colitis School of Pharmaceutical Sciences| Dr. Hang Yin

Barcoded screening identifies nanocarriers for protein delivery to kidney School of Pharmaceutical Sciences| Dr. Juanjuan Du

Professor Zhang Yonghui from the School of Pharmaceutical Sciences and his collaborators published a paper in Cell to propose a strategy for oral drug development targeting integrins

Latest Research ExpressOn September 15, 2022, the Harvard Medical School and the School of Pharmaceutical Sciences of Tsinghua University jointly published a research article entitled “A general chemical principle for creating closure-stabilizing integrin inhibitors” in Cell, introducing the challenges in the research and development of small molecule drugs targeting integrins, and proposing ...

Ding Sheng and his team from the School of Pharmaceutical Sciences published groundbreaking research findings on totipotent stem cells in Nature

Professor Ding Sheng and his team from the School of Pharmaceutical Sciences have discovered for the first time a drug combination for in vitro directed induction and stable culturing of totipotent stem cells. The breakthrough research findings were published online by Nature on June 21, 2022 (Beijing Time). The research marks the opening of a whole new field of life creation research.1. Revolu...

Yonghui ZHANG publishes "The mevalonate pathway is a druggable target for vaccine adjuvant discovery" in Cell

HighlightsLipophilic statins and lipophilic bisphosphonates are potent vaccine adjuvantsModulation of post-translational protein prenylation confers adjuvanticityDecreased protein prenylation augments antigen preservation and presentationStatin- or bisphosphonate-mediated vaccination synergizes with anti-PD1 against cancer SummaryMotivated by the clinical observation that interruption of the me...