DONG,Zhongjun-School of Medicine, Tsinghua University

Immunology

DONG,Zhongjun

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Tel: +86-10-62785852
E-mail: dongzj@tsinghua.edu.cn
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    Learning and working experience

    2000-2003 Shandong Academy of Medical Science, Master

    2003-2006 University of Science and Technology of China, Ph.D.

    2006-2011 Clinical Research Institute of Montreal, Postdoc

    2011-Present Institute for Immunology and School of Medicine, Tsinghua University, PI

    The main reward

    2013: Young Investigator Award, NSFC

    2012-2016: Janssen-Tsinghua Scholar

    2008-2011: fellowship Canadian Institutes of Health Research (CIHR) Fellowship

    2006: The First-class of Chinese Medical Science and Technology Award

    2005: Presidential Scholarship of Chinese Academy of Sciences (CAS)

Basic Biology of Natural Killer cells, Tumor Immunology

1.Transcriptional Regulation of NK cell Development

2. New Insight into NK cell Education

3. NK cell-Based Biotherapy and Translational Medicine

1.Fu B, Zhou Y, Ni X, Tong X, Xu X,Dong Z, Sun R, Tian Z, Wei H. Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.Immunity. 2017 Dec 19;47(6):1100-1113.

2.Lee YH, Martin-Orozco N, Zheng P, Li J, Zhang P, Tan H, Park HJ, Jeong M,Chang SH, Kim BS, Xiong W, Zang W, Guo L, Liu Y,Dong ZJ,Overwijk WW, Hwu P, Yi Q, Kwak L, Yang Z, Mak TW, Li W, Radvanyi LG, Ni L, Liu D, Dong C. Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function.Cell Res. 2017 Aug;27(8):1034-1045.

3.Chen S#, Cai C#, Li Z#, Liu GW, Wang Y, Blonska M, Dan Li D, Du J, Lin X, Yang M, andDong Z*. Genetic Dissection of SAP-dependent and SAP-independent SLAM Family Signaling in NKT Cell Development and Humoral Immunity,Journal Experimental Medicine. 2017 Jan 3. doi: 10.1084/jem.20161312.

4.Huang J, Yuan Q, Zhu H, Yin L, Hong S,Dong Z, Jin W, Dong C*. Interleukin-17C/IL-17RE amplifies T cell function in autoimmune hepatitis.J Immunol.2016 Dec 12. pii: 1600977.

5.Chen S#, Yang M#, Du J, Li D, Li ZH, Cai C, Ma Y, Zhang Y, Tian Z*, andDong Z*. The self-specific activation receptor SLAM family is critical to NK cell education.Immunity. 2016 Aug 16;45(2):292-304.

6.Yang M#, Chen S#, Du J, He J, Wang Y, Zehua, Li Z, Liu G, Peng W, Zeng X, Li D, Xu P, Guo W, Chang Z, Wang S, Tian Z andDong Z*. NK cell development requires Tsc1-dependent negative regulation of IL-15-trgiggered mTORC1 activation.Nature Communications. 2016 Sep 7;7:12730. doi: 10.1038/ncomms12730

7.Wu N, Zhong MC, Roncagalli R, Pérez-Quintero LA, Guo H, Zhang Z, Lenoir C,Dong Z, Latour S, Veillette A. A hematopoietic cell-driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education.Nature Immunology. 2016 Apr;17(4):387-96.

8.Du J, Yang MX, Chen SS, Li D, Chang Z, andDong Z* PDK1 promotes tumor growth and metastasis in a spontaneous breast cancer model.Oncogene, 2016;35(25):3314-23.

9.Yang M, Li D, Chang Z, Yang Z, Tian Z,Dong Z*. PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness.Journal Experimental Medicine. 2015 212(2):253-65.

10.Chu C, Wang Y, Zhang X, Ni X, Cao J, Xu W,Dong Z, Yuan P, Wei W, Ma Y, Zhang L, Wu L, Qi H. SAP-regulated T Cell-APC adhesion and ligation-dependent and-independent Ly108-CD3ζ interactions.J Immunol. 2014 Oct 15;193(8):3860-71.

11.Dong Z*, Dong C. Cancer-associated inflammation and tumor microenvironment.Cancer J. 2013 Nov-Dec;19(6):459-60.

12.Dong Z*, Davidson D, Pérez-Quintero L.A, Kurosaki T, Swat W, and Veillette A. The Adaptor SAP Controls NK Cell Activation by Regulating the Enzymes Vav-1 and SHIP-1 and by Enhancing Conjugates with Target Cells.Immunity, 2012; 36(6):974-85.

13.Guimont-Desrochers F, Boucher G,Dong Z, Dupuis M, Veillette A, Lesage. Redefining interferon-producing killer dendritic cells as a novel intermediate in NK cell differentiation.Blood;119(19):4349-57.

14.Dong Z, Veillette A. How do SAP family deficiencies compromise immunity?Trends in Immunology; 2010 Aug;31(8):295-302

15.Veillette A,Dong Z, Zhong M, Cruz-Munoz ME. Importance and mechanism of “switch” function of SAP family adaptors.Immunological Reviews. 2009,232(1); 2009:229-39.

16.Dong Z, Cruz-Munoz ME, Zhong M, Chen R, Latour S and Veillette A. Essential role of SAP family adaptors in natural killer cell surveillance of hematopoietic cells.Nature Immunology; 10(9); (2009):973-80.

17.Cruz-Munoz ME,Dong Z, Shi X, Zhang S, Veillette A. Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function.Nature Immunology; 10(3); (2009):297-305.

18.Veillette A, Zhang S, Shi X,Dong Z, Davidson D and Zhong M. SAP expression in T cells, not in B cells, is required for humoral immunity.PNAS; 105(4); (2008):1273-8

19.Dong Z, Zhang J, Sun R, Wei H, Tian Z. Impairment of liver regeneration correlates with activated hepatic NKT cells in HBV transgenic mice.Hepatology;45(6); (2007):1400-12.

20.Veillette A,Dong Z, Latour S. Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes.Immunity; 27(5); (2007):698-710.

21.Chen Y, Wei H, Sun R,Dong Z, Zhang J, Tian Z. Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells.Hepatology; 46(3); (2007):706-15.

22.Wang J, Sun R, Wei H,Dong Z, Gao B, Tian Z. Poly I:C prevents T cell-mediated hepatitis via an NK-dependent mechanism.Journal of Hepatology; 44(3) ;(2006):446-54.

23.Dong Z, Tian Z. APC-independent NK cell activation.Journal of Immunology. 2005 15;175(4):2041

24.Dong Z, Wei H, Sun R, Hu Z, Gao B, Tian Z. Involvement of natural killer cells in Poly I:C- induced liver injury.Journal of Hepatology; 41(6) ;(2004):966-73.