2019-presentProfessor, School of Medicine, Tsinghua University
2018-presentPrincipal Investigator, Tsinghua-PKU, Center of Life Science
2017-2019Tenured Associate professor, School of Medicine, Tsinghua University
2014-2017Tenure-track Associate professor, School of Medicine, Tsinghua University
2010-2014Principal Investigator, School of Medicine, Tsinghua University
2007-2010Postdoctoral Fellow, Harvard-MIT Division of Health Science and Technology, MIT; Harvard Medical School, Harvard University, USA
2003-2007Ph.D. in Bioengineering, National University of Singapore, Singapore
1998-2002B.Eng. in Chemical Engineering, Tsinghua University, Beijing, China
We have been innovating in the field of ‘Microtissue Engineering’, with accomplishment in the theoretical elucidation and technological translation. Microtissue Engineering integrates biomaterials, microfabrication, biophysical and gene editing technologies to engineer and fine-tune the microscale 3D cell or tissue microenvironments, whichprovides innovative and effective tools and solutions for regenerative medicine, drug discovery and pathology study. We focus on1)establishment of stem cell microenvironment, immune cell microenvironment as well as fibrosis pathological microenvironments; 2)the mechanism investigation of cell-cell, cell-matrix interactions and3)their translational applications in regenerative medicine.
Specifically, through theconstruction of 3D stem cell micro-tissue, large-scale/high-quality in vitro stemcell manufacture and minimally invasive, targeted, efficient in vivo delivery andregeneration treatment have been accomplished; meanwhile, the 3D pathological micro-tissuearray technology realized high-throughput and accurate anti-fibrosis drugscreening and evaluation. The new pathological mechanism of cell mechanicalcommunication based on 'paratensile signaling' in the development of tissuefibrosis was discovered. 2patents of micro-tissue engineering have been commercially translated with relatedproducts approved as the first cell pharmaceutical excipients by both China CDE and US FDA.