1. Yan A, Xiong J, Zhu J, Li X, Xu S, Feng X, Ke X, Wang Z, Chen Y, Wang HW, Zhang MQ*, Kee K*. DAZL regulates proliferation of human primordial germ cells by direct binding to precursor miRNAs and enhances DICER processing activity. Nucleic Acids Res. 2022 Oct 24:gkac856. doi: 10.1093/nar/gkac856.

2. Hu W, Zeng H, Shi Y, Zhou C, Huang J, Jia L, Xu S, Feng X, Zeng Y, Xiong T, Huang W, Sun P, Chang Y, Li T, Fang C, Wu K, Cai L, Ni W, Li Y, Yang Z, Zhang QC, Chian R, Chen Z, Liang X*, Kee K*. Single-cell transcriptome and translatome dual-omics reveals potential mechanisms of human oocyte maturation. Nat Commun. 2022 Aug 30;13(1):5114. doi: 10.1038/s41467-022-32791-2.

3. Chen B, Zhu G, Yan A, He J, Liu Y, Li L, Yang X, Dong C, Kee K*. IGSF11 is required for pericentric heterochromatin dissociation during meiotic diplotene. PLoS Genet. 2021 Sep 7;17(9):e1009778. doi: 10.1371/journal.pgen.1009778.

4. Li L, Yang R, Yin C, Kee K*. Studying human reproductive biology through single-cell analysis and in vitro differentiation of stem cells into germ cell-like cells. Hum Reprod Update. 2020 Sep 1;26(5):670-688. doi:10.1093/humupd/dmaa021.

5. Liang J, Wang N, He J, Du J, Guo Y, Li L, Wu W, Yao C, Li Z, Kee K*. Induction of Sertoli-like cells from human fibroblasts by NR5A1 and GATA4. Elife. 2019 Nov 11;8. pii: e48767. doi: 10.7554/eLife.48767.

6. Jung D, Xiong J, Ye M, Qin X, Li L, Cheng S, Luo M, Peng J, Dong J, Tang F, Shen W, Matzuk MM, Kee K*. In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells. Nat Commun.2017 Jun 12;8:15680. doi:10.1038/ncomms15680.

7. Li L, Wang B, Zhang W, Chen B, Luo M, Wang J, Wang X, Cao Y*, Kee K*. (2017). A homozygous NOBOX truncating variant causes defective transcriptional activation and leads to primary ovarian insufficiency. Hum Reprod 32(1): 248-255. doi:10.1093/humrep/dew271.

8. Li L, Zhou X, Wang X, Wang J, Zhang W, Wang B, Cao Y*, Kee K*. (2016). A dominant negative mutation at the ATP binding domain of AMHR2 is associated with a defective anti-Mullerian hormone signaling pathway. Mol Hum Reprod 22(9): 669-678. doi:10.1093/molehr/gaw040.

9. Lin J, Chen H, Luo L, Lai Y, Xie W, Kee K*. (2015). Creating a monomeric endonuclease TALE-I-SceI with high specificity and low genotoxicity in human cells. Nucleic Acids Res 43(2): 1112-1122. doi: 10.1093/nar/gku1339.

10. Kee K, Angeles VT, Flores M, Nguyen HN, Reijo Pera RA*. (2009). Human DAZL, DAZ and BOULE genes modulate primordial germ-cell and haploid gamete formation. Nature 462(7270): 222-225. doi: 10.1038/nature08562.

学术荣誉与奖励

2010/2011/2017拜耳研究员奖

2014 强生研究员奖

2014 清华大学良师益友奖

开设课程

医学细胞生物学

干细胞生物学

其他社会职务

2015年-至今英国医学研究委员会(MRC), 基金评委

2013年-至今中国科技部基金评委

2016年-至今 北京市科委干细胞专项基金评委

2012年-2017中国生殖生物学国家重点实验室, 学术顾问

2011年-至今中国自然科学基金评委,重大项目顾问与基金评委

2012年-至今 清华医学院干细胞伦理委员会委员

2017年-至今 协和医学院干细胞伦理委员会委员

2019年-至今中国动物学分会生殖生物学分会委员

2019年-至今中国载人航天工程空间科学空间生命科学与生物技术专家组

专利技术

1.美国专利:9920300; Induction of germ cells from pluripotent cells; Inventors: Kee, Kehkooi; Reijo Pera, Renee.

2.中国专利:201410730391.2; 特异识别并修复β地中海贫血症beta-globin基因的嵌合核酸酶; 发明人:纪家葵，林健飞

3.中国专利:201710373412.3; 专利名称：将人源胚胎干细胞体外诱导为卵泡的方法及其所用培养基; 发明人:纪家葵，叶旻

4.中国专利:201810712206.5; 专利名称：一种将成纤维细胞体外重编为Sertoli细胞的方法及其应用; 发明人:纪家葵，梁健霖