SONG Xiaolei-School of Medicine, Tsinghua University

Medical Imaging

SONG Xiaolei

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Dr. Xiaolei Song is an Associate Professor in Center for Biomedical Imaging Imaging Research (CBIR), and in Dept. of Biomedical Engineering, Tsinghua University. She obtained her Ph.D. in 2008 from Dept. of Biomedical Engineering at Tsinghua University. From 2009 to 2019 she From 2009 to 2019 she was working in Dept. of Radiology and Institute of Cell Engineering at Johns Hopkins University, firstly as a postdoctoral fellow, and then as a Research Associate and a tenure-tracked Assistant Professor.

Prof. Song's research interest is novel MRI and multi-modality imaging techniques, with smart multi-”omics”analysis, for visualization of molecular and cellular events in pre-clinical and clinical applications. Heracademic career was fostered by more than 15 years of extensive training and experience in biomedicalmolecular imaging, with a focus on fluorescence molecular tomography and Chemical ExchangeSaturation Transfer (CEST-MRI). She has been inventing in vivo imaging techniques for sensinginflammation,glycosylation levels of certain proteins and other metabolic changes in various diseases

including cancers and neurological disorders.

She has published more than 40 peer-reviewed papers on high-ranked journals including Nature Communication,J. of Cerebral Blood Flow and Metabolism,Angewandte Chemie,Magnetic Resonance in Medicine, NMR in Biomedicine和Optics Express. Till June 2021, her total citation in Google Scholar is 1500, with H-index of 19.

1. Song X, Airan RD, Arifin DR, Bar-Shir A, Kadayakkara DK, Liu G, Gilad AA, van Zijl PC, McMahon MT, Bulte JW. “Label-free in vivo molecular imaging of underglycosylated mucin-1 (uMUC1) expression in tumor cells”, Nature Communications. 2015, 6: 6719.

2. Song X, Walczak P, He X, Yang X, Pearl M, Bulte JW, Pomper MG, McMahon MT, Janowski M. “Salicylic Acid Analogues as Chemical Exchange Saturation Transfer MRI Contrast Agents for the Assessment of Brain Perfusion Territory and Blood-Brain Barrier Opening after Intra-Arterial Infusion” , J. Cereb. Blood Flow Metab. 2016, 36(7): 1186-94

3. Song X, Xu J, Xia S, Yadav NN, Lal B, Laterra J, Bulte JW, van Zijl PC, McMahon MT. “A Multi-echo Length and Offset VARied Saturation (MeLOVARS) Method for Improved CEST Imaging”, Magn. Res. Med. 2015, 73 (2): 488-496.

4. Yang X#, Song X#, Li Y, Liu G, Banerjee SR, Pomper MG, McMahon MT. “Salicylic Acid and Analogues as diaCEST MRI Contrast Agents with Highly Shifted Exchangeable Proton Frequencies”. 2013, Angew. Chem. Int. Ed. 52: 8116-8119.

5. Liu T, Chen Y, Thomas A, Song X*. “CEST MRI with distribution-based analysis for assessment of early stage disease activity in a mouse model of multiple sclerosis: an initial study”. NMR Biomed, 2019, 32(11): e4139 . doi: 10.1002/nbm.4139. Epub 2019 Jul 25.

LIU, Jing