NA, Jie-School of Medicine, Tsinghua University

Cell and Molecular Biology

NA, Jie

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Tel: +86-10-62781094
E-mail: Jie.na@tsinghua.edu.cn
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    1992-1997, Bachelor in Medicine, Peking University Health Science Center

    1997-2002, Ph.D. in Cell Biology, University of Virginia, USA

    2002-2005, Postdoc. The Welcome Trust Gurdon Institute, University of Cambridge, UK

    2005-2009, The Medical Research Council Stem Cell Career Development Fellow, University of Sheffield, UK

    2010-present, Principal Investigator and Associate Professor, Center for Stem Cell Biology, School of Medicine, Tsinghua University, Beijing, China

Pluripotent Stem Cells, Cardiovascular cell differentiation, Epigenetics, Regenerative medicine, Mammalian embryo development, organoid, 3D Bioprinting.

Dr Jie Na’s research fields are stem cell biology and regenerative medicine, and early mammalian embryo development. The main research emphasis are:

1.The molecular mechanism of human pluripotent stem cells differentiation to cardiovascular andblood lineagetissuesincludingcardiomyocytes, blood vessel cells andimmune cells.we also carry outtranslational research, aimingto usecell and gene therapy to treat ischemic diseases.

2.Investigate early mammalian embryo development and human diseases usingstem cellsgenerated organoids, explore theirapplication in drug testing and precision medicine.

3.Cardiovascular tissue engineering and 3D bioprinting.

    2011-2016:Janssen Tsinghua Investigator

    2009-2010:Welcome Trust Value in People Award

1.Jing Zhang, Adam J. Hirst, Fuyu Duan, Hui Qiu, Rujin Huang, Ying Ji, Lufeng Bai, Fengzhi Zhang, Darren Robinson, Mark Jones, Le Li, Peizhe Wang, Peng Jiang, Peter W. Andrews, Ivana Barbaric* andJie Na*. Anti-apoptotic mutations desensitise human pluripotent stem cells to mitotic stress and enable aneuploid cell survival. (2019)Stem Cell Reports. PMID:30773485, DOI: 10.1016/j.stemcr.2019.01.013

2.Hong Li, Huimin Zhu, FengzhiZhang, Xiaohui Dong, Tong Hao, Xiaoxia Jiang, Weibo Zheng, Tao Zhang, Xi Chen, Peizhe Wang,Jie Na*, Changyong Wang*, and Jin Zhou*. Spaceflight Promoted Myocardial Differentiation of Induced Pluripotent Stem Cells – Results from Tianzhou-1 Mission. (2019)Stem Cells and Development. DOI: 10.1089/scd.2018.0240. PMID: 30654722.

3.Jin Zhou, Xiao-Hui Dong, Feng-Zhi Zhang, Hui-Min Zhu, Tong Hao, Xiao-Xia Jiang, Wei-Bo Zheng, Tao Zhang, Pei-Zhe Wang, Hong Li*,Jie Na*,Chang-Yong Wang*. Real microgravity condition promoted regeneration capacity of induced pluripotent stem cells during the TZ-1 space mission. (2019)Cell Proliferation, e12574. DOI: 10.1111/cpr.12574. PMID:30724402.

4.Xi Chen, Lin Wang, Rujin Huang, Hui Qiu, Peizhe Wang, Daren Wu, Yonglin Zhu, Jia Ming, Yangming Wang, Jianbin Wang andJie Na*. (2018)Dgcr8Deletion in the Primitive Heart Uncovered Novel MicroRNA Regulating the Balance of Cardiac-Vascular Gene Program.(2018)Protein&Cell, Aug 20. [Epub ahead of print].PMID:30128894, DOI:10.1007/s13238-018-0572-1

5.Jingyi Wu, Jiawei Xu, Bofeng Liu, Guidong Yao, Peizhe Wang, Zili Lin, Bo Huang, Xuepeng Wang, Tong Li, Senlin Shi, Nan Zhang, Fuyu Duan, Jia Ming, Xiangyang Zhang, Wenbin Niu, Wenyan Song, Haixia Jin, Yihong Guo, Shanjun Dai, Linli Hu, Lanlan Fang, Qiujun Wang, Yuanyuan Li, Wei Li,Jie Na*,Wei Xie*andYingpu Sun*. Chromatin analysis in human early development reveals epigenetic transition during ZGA. (2018)Nature, 557:256-260. PMID:29720659, DOI: 10.1038/s41586-018-0080-8

6.Fuyu Duan, Rujin Huang, Fengzhi Zhang, Yonglin Zhu, Lin Wang, Xia Chen, Lufeng Bai, Wei Guo, Sophia Chia-Ning Chang, Xiaoyu Hu andJie Na*. Biphasic modulation of insulin signaling enables highly efficient hematopoietic differentiation from human pluripotent stem cells. (2018)Stem Cell Research & Therapy. 9(1):205. PMID:30053898, DOI:10.1186/s13287-018-0934-x

7.Wenzhi Li, Peizhe Wang, Bingjie Zhang, Jing Zhang, Jia Ming, Wei Xie andJie Na*. Differential regulation of H3S10 phosphorylation, mitosis progression and cell fate by Aurora Kinase B and C in mouse preimplantation embryos. (2017)Protein&Cell. 8(9):662-674. doi: 10.1007/s13238-017-0407-5.

8.Lu Wang, Xuanhao Xu, Yaqiang Cao, Zhongwei Li, Hao Cheng, Gaoyang Zhu, Fuyu Duan,Jie Na, Jing-Dong J. Han, and Ye-Guang Chen. Activin/Smad2-induced Histone H3 Lys-27 Trimethylation (H3K27me3) Reduction Is Crucial to Initiate Mesendoderm Differentiation of Human Embryonic Stem Cells. (2017)The Journal of Biological Chemistry, 292:4, 1339-1350

9.Jianying Guo, Dacheng Ma, Rujin Huang, Jia Ming, Min Ye, Kehkooi Kee, Zhen Xie, andJie Na*. An inducible CRISPR-ON system for controllable gene activation in human pluripotent stem cells. (2017)Protein&Cell, 8(5):379-393. PMID:28116670, DOI: 10.1007/s13238-016-0360-8.

10.Fengzhi Zhang, Lin Wang, Yaqian Li, Wei Liu, Fuyu Duan, Rujin Huang, Xi Chen, Sophia Chia-Ning Chang, Yanan Du andJie Na*.Optimizing mesoderm progenitor selection and three-dimensional microniche culture allows highly efficient endothelial differentiation and ischemic tissue repair from human pluripotent stem cells. (2017)Stem Cell Research & Therapy, 8(1):6. PMID:28114972, DOI: 10.1186/s13287-016-0455-4

11.Bingjie Zhang, Hui Zheng, Bo Huang, Wenzhi Li, Yunlong Xiang, Xu Peng, Jia Ming, Xiaotong Wu, Yu Zhang, Qianhua Xu, Wenqiang Liu, Xiaochen Kou, Yanhong Zhao, Wenteng He, Chong Li, Bo Chen, Yuanyuan Li, Qiujun Wang, Jing Ma, Qiangzong Yin, Kehkooi Kee, Anming Meng, Shaorong Gao, Feng Xu,Jie Na*andWei Xie*.Allelic reprogramming of the histone modification H3K4me3 in early mammalian development.(2016)Nature, 537:553-557.PMID:27626382, DOI:10.1038/nature19361

12.Jingyi Wu, Bo Huang, He Chen, Qiangzong Yin, Yang Liu, Yunlong Xiang, Bingjie Zhang, Bofeng Liu, Qiujun Wang, Weikun Xia, Wenzhi Li, Yuanyuan Li, Jing Ma, Xu Peng, Hui Zheng, Jia Ming, Wenhao Zhang, Jing Zhang, Geng Tian, Feng Xu, Zai Chang,Jie Na, Xuerui Yang & Wei Xie*. The landscape of accessiblechromatin in mammalian preimplantation embryos.(2016)Nature,534:652-657.PMID:27309802, DOI:10.1038/nature18606

13.Sai Luo, J.Yuyang Lu, Lichao Liu, Yafei Yin, Chunyan Chen, Xue Han, Bohou Wu, Ronggang Xu, Wei Liu, Pixi Yan, Wen Shao, Zhi Lu, Haitao Li,Jie Na, Fuchou Tang, Jianlong Wang,Yong E.Zhang, Xiaohua Shen*.Divergent lncRNAs Regulate Gene Expression and Lineage Differentiation in Pluripotent Cells.(2016)Cell Stem Cell,18, 1–16.PMID:26996597, DOI:10.1016/j.stem.2016.01.024

14.Liliang Ouyang, Rui Yao, Shuangshuang Mao, Xi Chen,Jie Naand Wei Sun*. Three-dimensional bioprinting of embryonic stem cells directs highly uniform embryoid body formation.(2015)Biofabrication, 7(4), 044101.PMID:26531008, DOI:10.1088/1758-5090/7/4/044101

15.Liliang Ouyang, Rui Yao, Xi Chen,Jie Na*and Wei Sun*. 3D printing of HEK 293FT cell-laden hydrogel into macroporous constructs with high cell viability and normal biological functions.(2015)Biofabrication, 7(1), 015010. PMID:25691496,DOI:10.1088/1758-5090/7/1/015010

16.Jie Na*, Duncan Baker, Jing Zhang, Peter W. Andrews, Ivana Barbaric*. Aneuploidy in pluripotent stem cells and implications for cancerous transformation.(2014)Protein&Cell,5(8):569–579. PMID:24899134, DOI:10.1007/s13238-014-0073-9

17.Hongjie Liu, Zhaoting Wu, Xianle Shi, Wenzhi Li, Chang Liu, Dekun Wang, Xiaoying Ye, Lin Liu,Jie Na*, Hong Cheng*and Lingyi Chen*.Atypical PKC, regulated by Rho GTPases and Mek/Erk, phosphorylates Ezrin during eight-cell embryo compaction.(2013)Developmental Biology.375(1):13-22. PMID:23313818, DOI:10.1016/j.ydbio.2013.01.002

18.Peizhe Wang andJie Na*. Reprogramming to pluripotency and differentiation of cells with synthetic mRNA.(2013)Methods inMolecular Biology.969:221-33.PMID:23296937, DOI: 10.1007/978-1-62703-260-5_14

19.Jordan R.Plews,JianliangLi,MarkJones,Harry D.Moore,ChrisMason,Peter W.Andrews,JieNa*. Activation of pluripotency genes in human fibroblast cells by a novel mRNA based approach. (2010)PLoS One,5(12):e14397. DOI: 10.1371/journal.pone.0014397. PMID:21209933.

20.Sharif B#,Na J#, Lykke-Hartmann K, McLaughlin SH, Laue E, Glover DM, Zernicka-Goetz M: The chromosome passenger complex is required for fidelity of chromosome transmission and cytokinesis in meiosis of mouse oocytes. (2010)Journal of Cell Science,123(Pt 24):4292–4300. DOI: 10.1242/jcs.067447, PMID:21123620.#Co-first authors.

21.JieNa*,Miho K.Furue,Peter W.Andrews. Inhibition of ERK1/2 prevents neural and mesendodermal differentiation and promotes human embryonic stem cell self-renewal. (2010)Stem Cell Research,5(2):157-69. DOI: 10.1016/j.scr.2010.06.002, PMID:20675210.

22.Furue MK,Na J, Jackson JP, Okamoto T, Jones M, Baker D, Hata R, Moore HD, Sato JD, Andrews PW: Heparin promotes the growth of human embryonic stem cells in a defined serum-free medium. (2008)Proc Natl Acad Sci U S A. 105(36):13409–13414. DOI: 10.1073/pnas.0806136105. PMID:18725626.