WANG Yating-School of Medicine, Tsinghua University

Microbiology and Infectious Diseases

WANG Yating

Contact Us：
Tel: +86-10-62799141
E-mail: yatingwang at tsinghua.edu.cn
WeChat public account：

    2021-present Assistant professor,

    Tsinghua University School of Medicine, Beijing

    2015-2021 Postdoctoral Research Associate

    Washington University School of Medicine, St. Louis, MO, USA

    2008-2014 Doctor of Philosophy

    The University of Chicago, Chicago, IL, USA

    2004-2008 Bachelor of Science (Biology)

    Nankai University, Tianjin, China

We study issues at the interface between microbiology and immunology, working from the hypothesis that pathogenic microbes manipulate the immune response using immune evasive gene products as the immune response attempts to eradicate the microbes. This delicate balance determines the fate of both pathogens and host. Most of the time, our immune system does a remarkable job of eliminating infectious microbes before they cause problem. But some microbes can cause severe life-threatening disease. We are interested in the fundamental mechanisms that provide successful host defense. We are also interested in the pathogens’strategy to evade host immunity.

1. Feng S, McNehlan ME, Kinsella RL, Chowdhury CS, Chavez SM, Naik SK, McKee SR, Van Winkle JA, Dubey N, Samuels A, Swain A, Cui X, Hendrix SV, Woodson R, Kreamalmeyer D, Smirnov A, Artyomov MN, Virgin HW, Wang YT#, Stallings CL#. Autophagy Promotes Efficient T Cell Responses to Restrict High-Dose Mycobacterium Tuberculosis Infection in Mice. Nature Microbiol. 2024

2. Wang YT, Sansone A, Smirnov A, Stallings CL, Orvedahl A. Myeloid autophagy genes protect mice against fatal TNF- and LPS-induced cytokine storm syndromes, Autophagy, 2023 19:4, 1114-1127.

3. Balce DR,Wang YT, McAllaster MR, Dunlap BF., Orvedahl A, Hykes B, Droit L, Handley SA, Wilen CB, Doench JG, Orchard RC, Stallings SL, Virgin HW. UFMylation inhibits the pro-inflammatory capacity of interferon-γ-activated macrophages. Proc Natl Acad Sci USA. 2021 Jan 5;118(1):e2011763118.

4.Wang YT#, Zaitsev K, Lu Q, Li S, Schaiff WT, Kim KW, Droit L, Wilen CB, Desai C, Balce DR, Orchard RC, Orvedahl A, Park S, Kreamalmeyer D, Handley SA, Pfeifer JD, Baldridge MT, Artyomov MN, Stallings CL#, Virgin HW#. Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes. Nat Microbiol. 2020 Feb;5(2):272-281. #corresponding author.

5. Orvedahl A, McAllaster MR, Dunlap B, Sansone A, Desai C,Wang YT,Balce DR, Luke CJ, Lee S, Orchard RC, Artyomov MN, Handley SA, Doench JG, Silverman GA, Virgin HW. Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock. Proc Natl Acad Sci USA. 2019 Aug13;116(33):16497-16506.

6. Wilen CB, Lee S, Hsieh LL, Orchard RC, Desai C, Hykes BL Jr, McAllaster MR, Balce DR, Feehley T, Brestoff JR, Hickey CA, Yokoyama CC,Wang YT,MacDuff DA, Kreamalmayer D, Howitt MR, Neil JA, Cadwell K, Allen PM, Handley SA, van Lookeren Campagne M, Baldridge MT, Virgin HW. Tropism for tuft cells determines immune promotion of norovirus pathogenesis. Science. 2018 Apr 13;360(6385):204-208.

7. Kim KW, Williams JW,Wang YT,Ivanov S, Gilfillan S, Colonna M, Virgin HW, Gautier EL, Randolph GJ. MHC II+ resident peritoneal and pleural macrophages rely on IRF4 for development from circulating monocytes. J Exp Med. 2016 Sep 19;213(10):1951-9.

8. Zhang J, Liu H, Zhu K, Gong S, Dramsi S,Wang YT,Li J, Chen F, Zhang R, Zhou L, Lan L, Jiang H, Schneewind O, Luo C, Yang CG. Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase. Proc Natl Acad Sci USA. 2014 Sep 16;111(37):13517-22.

9.Wang YT,Missiakas D, Schneewind O. GneZ, a UDP-GlcNAc 2-epimerase, is required for S-layer assembly and vegetative growth of Bacillus anthracis. J Bacteriol. 2014 Aug 15;196(16):2969-78.

10. Deng FK, Zhang L,Wang YT,Schneewind O, Kent SB. Total chemical synthesis of the enzyme sortase A(ΔN59) with full catalytic activity. Angew Chem Int Ed Engl. 2014 Apr 25;53(18):4662-6.

11. Lunderberg JM, Nguyen-Mau SM, Richter GS,Wang YT,Dworkin J, Missiakas DM, Schneewind O. Bacillus anthracis acetyltransferases PatA1 and PatA2 modify the secondary cell wall polysaccharide and affect the assembly of S-layer proteins. J Bacteriol. 2013 Mar;195(5):977-89.

12.Wang YT, Oh SY, Hendrickx AP, Lunderberg JM, Schneewind O. Bacillus cereus G9241 S-layer assembly contributes to the pathogenesis of anthrax-like disease in mice. J Bacteriol. 2013 Feb;195(3):596-605.

13. Garufi G*,Wang YT*, Oh SY, Maier H, Missiakas DM, Schneewind O. Sortase-conjugation generates a capsule vaccine that protects guinea pigs against Bacillus anthracis. Vaccine. 2012 May 14;30(23):3435-44. *co-first author.