LIN,xin-School of Medicine, Tsinghua University



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    · Shanghai University of Science and Technology, B.Sc.

    · University of Texas Health Science Center, Ph.D.

    · UCSF, Gladstone Institute of Virology & Immunology, Postdoc

    · SUNY School of Medicine, Buffalo, Assistant Professor

    · University of Texas, MD Anderson Cancer Center, Associate Professor, Professor, Endowed Professor

    · University of Texas, MD Anderson Cancer Center, Center for Inflammation and Cancer, Associate Director

    · University of Texas, Graduate School of Biomedical Sciences, Cancer Biology Program, Director

    · Tsinghua University, School of Medicine, Department of Basic Medical Sciences, Professor and Chairman

Lin lab is focused on basic biology and clinical application of immune system and cancer. The major research projects are to determine the molecular mechanism by which NF-kB is activated by various signaling pathways, and to investigate the mechanism by which NF-kB is linked to T lymphocytes activation, inflammation and its contribution to the malignancy of various cancers, developing technology platforms for cancer immunotherapy.

    National Expert Award

    Cheung Kong Lecture Professorship

    Cancer Research Institute (New York), Investigator Award

    Leukemia and Lymphoma Society, Scholar Award

1.Wang, D.; You, Y.; Case, S.M.; Wang, L.; DiStefano, P.S., Nunez, G.; Bertin, J.;Lin, X.(2002) A requirement of CARMA1 in T cell receptor-induced NF-kB activation.Nature Immunology. 3(9): 830-5.

2.Wang, D.; Matsumoto, R.; You, Y.; Che, T.; Lin, X-Y; Gaffen, SL;Lin, X. (2004) CD3-CD28 costimulation-induced NF-kB activation is mediated by recruitment of PKC-q, Bcl10, and IKKbto the immunological synapse through CARMA1.Mol. Cell. Biol.24 (1), 164-171.

3.Che, T.; You, Y.; Wang, D.; Dixit, VM; Tanner, M.J.;Lin, X. (2004) MALT1/Paracaspase is a signaling component downstream of CARMA1 and mediates T cell receptor-induced NF-kB activation.J. Biol. Chem.279, 15870-15876.

4.Blonska, M.; You, Y.; Geleziunas, R.Lin, X.(2004) Restoration of NF-kB Activation by tumor necrosis factor-alpha receptor complex-targeted MEKK3 in Receptor-Interacting Protein-deficient cells.Mol. Cell. Biol.24 (24), 10757-10765.

5.Matsumoto, R.; Wang, D.; Blonska, M.; Li, H.; Kobayashi, M.; Pappu, B.; Chen, Y.; Wang, D.;Lin, X. (2005) Phosphorylation of CARMA1 plays a critical role in T cell receptor-induced NF-kB activation.Immunity,23, 1-11, 2005.

6.Blonska, M.; Shambharkar, P.B.; Kobayashi, M.; Zhang, D.; Sakurai, H.; Su, B.;Lin, X.(2005) TAK1 is recruited into TNFareceptor 1 complex through a RIP-dependent manner and cooperates with MEKK3 leading to NF-kB activation.J. Biol. Chem.280 (52) 43056-43063, 2005.

7.Li, H.; Kobayashi, M.; Blonska, M.; You, Y;Lin, X.(2006) Ubiquitination of RIP is required for TNFa-induced NF-kB activation.J. Biol. Chem.281 (19) 13636-43.

8.Pappu, B.;Lin, X. (2006) The role of CARMA1 in splenic B cell development and function.Eur. J. Immunol. 36 (11): 3033-43

9.Wang, D.; You, Y.; Lin, P.; Xue, L.; Morris, S.; Zeng, H.; Wen, R.,Lin, X. (2007) Bcl10 is required for G protein-coupled receptor-induced NF-kB activation.Proc. Natl. Acad. Sci. USA (Track II),104(1): 145-50.

10.Blonska, M.; Pappu, B.; Li, H.; Matsumoto R.; Su, B.; Wang, D.;Lin, X. (2007) The CARMA1-Bcl10 complex selectively regulates JNK2 in the T cell receptor signaling pathway.Immunity, 26(1): 55-66.

11.Hsu, MY, Zhang, Y.; You, Y.; Wang, D.; Li, H.; Duramad, O, Qin, X; Dong, C;Lin, X.(2007) CARD9 is required for innate immune responses against intracellular pathogens.Nature Immunology, 8(2): 198-205.

12.Shambharkar, P.B.; Blonska, M; Pappu, B.P.; Li, H.; You, Y.; Darnay, B.;Lin, X. (2007) Phosphorylation and ubiquitination of IKK complex by two distinct signaling pathways.EMBO J.26(7): 1794-805.

13.Grabiner, B.; Lin, P.; Blonska, M.; You, Y.; Wang, D.; Sun, J.; Darnay, BG; Dong, C.;Lin, X. (2007) CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-kB activation.GENES & DEVELPMENT.21(8): 984-96

14.Tanner, MJ; Hanel, W.; Gaffen, SL;Lin, X.(2007) CARMA1 Coiled-coil domain is involved in the oligomerization and subcellular localization of CARMA1, and is required for T cell receptor-induced NF-kB activation.J. Biol. Chem.282 (23): 17141-7

15.Sun J. andLin X.(2008)b-arrestin 2 is required for lysophosphatidic acid-induced NF-kB activation.Proc. Natl. Acad. Sci. USA. Nov 4;105(44):17085-90.

16.Wu W, Hsu YM, Bi L, Songyang Z,Lin X.(2009) CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex.Nature Immunology. Nov; 10(11):1208-14.

17.Bi L, Gorjestani S, Wu W, Hsu YM, Zhu J, Ariizumi K,Lin X(2010) CARD9 mediates Dectin-2-induced IKK ubiquitination leading to activation of NF-kappaB in response to the stimulation by the hyphal form ofCandida albicans.J. Biol. Chem.Aug 20; 285(34): 25969-77

18.Jiang T, Grabiner B, Zhu Y, Jiang C, Li H, You Y, Lang J, Hung M-C,Lin X(2011) CARMA3 is crucial for EGF-induced activation of NF-kB and tumor progression.Cancer Research. Mar 15; 71(6):2183-92.

19.Gorjestani S, Yu M, Tang B, D Zhang, Wang D,Lin X(2011) Phospholipase Cγ2 (PLCγ2) is a key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses. J. Biol. Chem.Dec 23; 285(51): 43651-43659

20.Blonska M., Joo D, Zweidler-McKay PA, Zhao Q,Lin, X. (2012) CARMA1 controls Th2 cell-specific cytokine expression through regulating JunB and GATA3 transcription factors.J Immunol.Apr 1; 188(7): 3160-8. Epub 2012 Feb 27.

21.Gorjestani S, Darnay B,Lin X(2012) TRAF6 and TAK1 play essential roles in C-type lectin receptor signaling in response toCandida albicansinfection.J. Biol. Chem.2012, Dec 28; 287(53): 44143-50.

22.Liu XK, Li H, Zhong B, Blonska M, Gorjestani S, Yan M, Tian Q, Zhang D,Lin X*, Dong C* (2013). USP18 inhibits NF-kB and NFAT activation during Th17 differentiation by deubiquitinating TAK1/TAB1 complex.J. Exp. Med.2013 Jul 29; 210(8): 1575-90.

*Co-corresponding authors

23.Zhu LL, Zhao XQ, Jiang CY, You Y, Chen XP, Jiang YY, Jia XM,Lin X(2013) C-type lectin receptors Dectin-3 (CLECSF8) and Dectin-2 form a heterodimeric pattern recognition receptor for host defense against fungal infection.Immunity,2013 Aug 22; 39(2):324-34.

24.Blonska M, Joo D, Nurieva RI, Zhao X, Chiao P, Sun S-C, Dong C,Lin X(2013) Activation of the Transcription Factor c-Maf in T Cells is Dependent on the CARMA1-IKKbSignaling Cascade.Science Signaling.Dec 17; 6(306): ra110. doi: 10.1126/scisignal.2004273.

25.Jia XM, Tang B, Zhu LL, Liu YH, Zhao XQ, Gorjestani S, Hsu Y-M, Yang L, Guan JH, Xu GT,Lin X(2014) CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for anti-fungal immunity.J Exp Med. 2014 Oct 20;211(11):2307-21.

26.Zhao XQ, Zhu L-L, Chang Q, Jiang C, Luo TM, You Y, Jia X-M, andLin X. (2014). C-type lectin Dectin-3 mediates trehalose 6,6'-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent NF-ĸB activation.J Biol Chem.2014 Oct 24; 289(43):30052-62

27.Blonska M, Zhu Y, Chuang H, You, JM, Kunkulla K, Vega F,Lin X(2015). Jun-regulated genes promote interaction of diffuse large B-cell lymphoma with the microenvironment.Blood2015 Feb 5;125(6):981-91.

28.Pan D, Jiang C, Ma Z, Blonska M, James You MJ, andLin X(2015) MALT1 is required for EGFR induced NF-kB activation and contributes to EGFR-driven lung cancer progression.Oncogene.2015 May 18. doi: 10.1038/onc.2015.146. [Epub ahead of print]

29.Pan D, Zhu Y, Zhou Z, Wang T, You H, Jiang C,Lin X. (2016)The CBM Complex Underwrites NF-kappaB Activation to Promote HER2-associated Tumor Malignancy.Mol Cancer Res.2016 Jan;14(1):93-102.

30.Jiang C, Zhou Z, Quan Y, Zhang S, Wang T, Zhao X, Morrison C, Heise MT,HeW,Miller MS, andLin X. (2016)CARMA3 is a host factor regulatingthe balance of inflammatory and antiviral responses against viral infection.Cell Reports.2016 Mar 15;14(10):2389-401.

31.Wang T, Pan, D, Zhou Z, Jiang C, You Y,andLin X(2016)Dectin-3Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the Gut.PLOS Pathogens2016 Jun 9;12 (6): e1005662. doi: 10.1371/journal.ppat.1005662. eCollection 2016 Jun.

32.Zhu LL, Luo TM, Xu X, Guo YH, Zhao XQ, Tang B, Jiang YY,Lin X*,Jia XM* (2016) E3-ubiquitin-ligase Cbl-b negatively regulates C-type lectin receptor-mediated anti-fungal innateimmunity.J Exp Med, 2016 Jul 25;213(8):1555-70.*Co-corresponding author

33.Joo D, Tang Y, Blonska M, Jin J, Zhao X,Lin X. (2016)Regulation of linear ubiquitin chain assembly complex by Caspase-mediated cleavage of RNF31.Mol Cell Biol.2016 Sep 26. pii: MCB.00474-16. [Epub ahead of print]

34.Jiang C, Zhu Y, Zhou Z, Gumin J, Bengtsson L, Wu W, Songyang Z, Lang FF,Lin X(2016) TMEM43/LUMA is a key signaling component mediating EGFR-induced NF-kB activation and tumor progression.Oncogene,2016 Dec 19. doi: 10.1038/onc.2016.430. [Epub ahead of print]

35.Zhao X, Guo Y, Jiang C, Chang Q, Zhang S, Luo T, Zhang B, Jia X, Hung MC, Dong C,Lin X(2017) JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression.NatureMedicine. 2017 Mar;23(3):337-346. doi: 10.1038/nm.4260. Epub 2017 Jan 23.

36.Zhang S, Pan D, Jia XM,Lin X*, Zhao X*. (2017).The CARMA3-BCL10-MALT1 (CBM) complex contributes to DNA damage-induced NF-κB activation and cell survival.Protein & Cell. 2017 Jul 17. doi: 10.1007/s13238-017-0441-3. [Epub ahead of print].

*Co-corresponding authors

37.Tang Y, Tu H, Liu G, Zheng G, Wang M, Li L, Zhao X, andLin X.(2018). RNF31 regulates skin homeostasis by protecting epidermal keratinocytes from cell death.J Immunol.2018 Jun 15;200(12):4117-4124

38.Xu X, Xu J, Zheng G, Lu H, Rui W, Guan J, Cheng L, Yang D, Wang M, Duan J, Lv Q, Li J, Zhao X, Chen C, Shi P, Jia X*,Lin X*.(2018). CARD9S12Nmutation converts alveolar macrophages into IL-5-producing cells and facilitates type 2 immune responses.Nature Immunology,2018 Jun;19(6):547-560.

39.Wang M, Zhang S, Zheng G, Huang J, Songyang Z, Zhao X,Lin X. (2018).Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17A.Immunity. 2018Jul 17;49(1):66-79

40.Zheng G, Jiang C, Yang D, Li Y, Ma Y, Zhang B, Li X, Zhang P, Hu X, Zhao X, Du J,Lin X.(2018). TMEM43-S358L mutation enhances NF-kB-TGFbsignal cascade and PPARgpathway in arrhythmogenic right ventricular dysplasia/cardiomyopathy.Protein & Cells2018 Jul 6. doi: 10.1007/s13238-018-0563-2. [Epub ahead of print]

41.Wang T, Fan C, Yao A, Xu X, Zheng G, You Y, Jiang C, Zhao X, Hung MC,Lin X.(2018). The adaptor protein CARD9 protects against colitis-associated colon cancer by restricting mycobiota-mediated expansion of myeloid-derived suppressor cells.Immunity,2018 Sep 18;49(3):504-514

42.Guo Y, Chang Q, Cheng L, Xiong S, Jia X,Lin X*, Zhao X*. (2018). C-type lectin receptor CD23 controls antifungal immunity through regulating nitric oxide production in activated macrophages.J Immunol.2018 Oct 15;201(8):2427-2440

*Co-corresponding authors

43.Tang Y, Joo D, Liu G, Tu H, You J, Jin J, Zhao X, Hung M,Lin X.(2018). Linear ubiquitination of cFLIP induced by LUBAC contributes to TNFa-induced apoptosis.J Biol Chem.2018 Dec 28;293(52):20062-20072

44.Cheng L, Deng N, Yang N, Zhao X, andLin X(2019) Malt1 protease is critical in maintaining function of Treg cells and may be a therapeutic target for anti-tumor immunity.J Immunol.May 15;202(10):3008-3019. doi: 10.4049/jimmunol.1801614. Epub 2019 Apr 12.

45.Yang D, Zhao X,Lin X(2019) Bcl10 is required for the development and suppressive function of Foxp3+regulatory T cells.Cell Mol Immunol. 2019 Oct 8. doi: 10.1038/s41423-019-0297-y. [Epub ahead of print]

46.Tang Y, Tu H, Zhang J, Zhao X,Lin X(2019). K63-linked ubiquitination regulatesRIPK1 kinase activity to prevent cell death during embryogenesis and inflammation.Nat Commun.2019 Sep 13;10(1):4157.

47.Liu G, Rui W, Zheng H, Huang D, Yu F, Zhang Y, Dong J, Zhao X, andLin X(2020) CXCR2-modified CAR-T cells have enhanced trafficking ability that improves treatment of hepatocellular carcinoma.Euro J Immunol.2020 Jan 24. doi: 10.1002/eji.201948457. [Epub ahead of print]