Research Fields & Emphasis
Inflammation, autoimmunity, macrophage, intestinal epithelium
Laboratory of Innate Effector Function
Ever since the days doing my undergraduate thesis work at an immunology lab in Beijing Medical University, I have always been intrigued by how immune cells integrate various exogenous and endogenous environmental cues to achieve optimal responses and have been fortunate enough to pursue this dream of deciphering immune responses via molecular approaches throughout most of my career. Meanwhile, given my training in medical school, it is equally important for me to underscore our research efforts with clinical relevance to ultimately achieve the goals of meeting pressing medical needs such as treating human autoimmunity and inflammatory diseases. Therefore, our current research efforts and directions largely stem from and are motivated by the desire to unravel immune regulatory mechanisms combined with the hope to discover new therapeutic targets for autoimmune and inflammatory disorders.
1. Investigate molecular mechanisms governing macrophage activation and polarization
2. Study biology of tissue-resident macrophages
3. Unravel regulatory mechanisms controlling functionality of intestinal epithelial cells
4. Discover novel therapeutic targets for autoimmune and inflammatory disorders
1. Xu H, Zhu J, Smith S, Foldi J, Zhao B, Chung AY, Outtz HH, Kitajewski J, Shi C, Weber S, Saftig P, Li YM, Ozato K, Blobel CP, Ivashkiv LB, Hu X. Notch-RBP-J signaling regulates IRF8 to promote inflammatory macrophage polarization. Nature Immunology 2012; 13:642-650
2. Shang Y, Coppo M, He T, Ning F, Yu L, Kang L, Zhang B, Ju C, Qiao Y, Zhao B, Gessler M, Rogatsky I, Hu X. The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongation. Nature Immunology 2016; 17:930-937
3. Liang S, Guo XK, Ou J, Huang R, Xue Q, Zhang B, Chung Y, Wu W, Dong C, Yang X, Hu X. Nutrient sensing by the intestinal epithelium orchestrates mucosal antimicrobial defense via translational control of Hes1. Cell Host & Microbe 2019; 25:706-718 (cover story accompanied by a preview article)
4. Ning F, Li Y, Yu L, Zhang B, Liu Y, Zhao B, Shang Y, Hu X. Transcription factor Hes1 attenuates type I interferon-mediated immune responses via VEGF-C and WDFY1. Journal of Experimental Medicine 2019; 216:1396-1410
5. Ji L, Zhao X, Zhang B, Kang L, Song W, Zhao B, Xie W, Chen L, Hu X. Slc6A8-mediated creatine uptake and accumulation reprogram macrophage polarization via regulating cytokine responses. Immunity 2019; 51:272-284
6. Kang L, Zhang X, Ji L, Kou T, Smith SM, Zhao B, Guo X, Pineda-Torra I, Wu L, Hu X. The colonic macrophage transcription factor RBP-J orchestrates intestinal immunity against bacterial pathogens. Journal of Experimental Medicine 2020; 217(4). pii: e20190762.
7. Yu L, Zhang B, Sacta MA, Rollins DA, Chinenov Y, Li R, Rogatsky I, Hu X. Negative elongation factor complex enables macrophage-mediated inflammatory responses by controlling expression of anti-inflammatory genes. Nature Communications 2020; 11:2286