ZHANG, Xiaoning-School of Medicine, Tsinghua University

Research Faculty

ZHANG, Xiaoning

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Tel: +86-10-62785489
E-mail: drugman@tsinghua.edu.cn
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    2014-2016 PI, 2011 Collaborative Innovation Center for Biotherapy

    2012-2016 CFDA Medical Apparatus Review Expert,NDRC Drug price Assesment Expert

    2011- present CFDA Drug Review Expert

    2008- present Senior Member, Chinese Pharmaceutical Association

    2004-present Associate Professor, PI of Pharmaceutics Lab, School of Medicine, Tsinghua University

    2002-2004 Postdoct, Department of Biosciences and Biotechnology, Tsinghua University

    2000-2002 Postdoct, Department of Physics, Tsinghua University

    1997-2000 Ph.D., Beijing Institute of Technology, Major in Material Science

    1994-1997 M.S., Beijing Institute of Technology, Major in Physical Chemistry

    1989-1993 B.S., Xi'an Jiaotong University, Major in Polymer Science

Nanobiotechnology and Nanomedicine:Design novel active targeting nano-drug delivery systems (NDDS) for tumor targeting and gene therapy; Develop novel NDDS for oral administration and novel transdermal drug delivery;Study the transport mechanism of NDDS to provide theoretical foundation for nanomedicine.

1.Jun Li, Jing Liu, Nana Guo, Xiaoning Zhang*. Reversal of multidrug resistance in breast cancer MCF-7/ADR cells by h-R3-siMDR1-PAMAM complexes. International Journal of Pharmaceutics. 2016, 511(1): 436-445.

2.Jun Li, Lei Chen, Nan Liu, Shengnan Li, Yanli Hao, Xiaoning Zhang *. EGF-coated nano-dendriplexes for tumor-targeted nucleic acid delivery in vivo. Drug Delivery. 3(5), 1718-1725, 2016.

3.Jun Li, Jing Liu, Shengnan Li, Yanli Hao, Lei Chen, Xiaoning Zhang*. Antibody h-R3 mediated siRNA has excellent endosomal escape and tumor targeted delivery ability, and represents efficient siPLK1 silencing and inhibition of cell proliferation, migration and invasion. Oncotarget. 2016, 7 (12): 13782-13796.

4.Jun Li, Shengnan Li, Songyun Xia, Jinfeng Feng, Yanli Hao, Lei Chen, Xiaoning Zhang*. Enhanced transfection efficiency and targeted delivery of self-assembling h-R3-dendriplexes in EGFR-overexpressing tumor cells. Oncotarget. 2015; 6: 26177-91. SCI, IF=6.359 (2014)

5.Yanli Hao*, Lan Wang, Jun Li, Nan Liu, Jinfeng Feng, Mojiao Zhao, Xiaoning Zhang*. Enhancement of solubility, transport across MDCK monolayer and oral absorption of pranlukast by preparing pranlukast-phospholipid complex. J. Biomedical Nanotechnology. 11(3), pp 469-477, 2015/3. SCI, IF=5.338 (2014)

6.Xiang Gao, Shimin Wang, BiLan Wang, Senyi Deng, Xiaoxiao Liu, XiaoNing Zhang, LinLi Luo, RangRang Fan, MingLi Xiang, Chao You, YuQuan Wei, ZhiYong Qian, Gang Guo.* Improving the anti-ovarian cancer activity of docetaxel with biodegradable self-assembly micelles through various evaluations. Biomaterials 53 (2015) 646-658. SCI, IF=8.557 (2014)

7.Cheng, Qiang; *Huang, Yuanyu; Zheng, Hua; Wei, Tuo; Zheng, Shuquan; Huo, Shuaidong; Wang, Xiaoxia; Du, Quan; Zhang, Xiaoning; Zhang, Hong-Yan; Liang, Xing-Jie; Wang, Chun; Tang, Rupei; Liang, Zicai*. The effect of guanidinylation of PEGylated poly(2-aminoethyl methacrylate) on the systemic delivery of siRNA . BIOMATERIALS, 34(12), pp 3120-3131, 2013/4. SCI,IF=8.557 (2014)

8.Mingshu Ma, Yanli Hao*, Nan Liu, Zhe Yin, Lan Wang, Xing-Jie Liang, Xiaoning Zhang*. A novel lipid-based nano-micelle of docetaxel: evaluated antitumor efficiency and biodistribution with optical imaging in vivo. In J Nanomedicine ,7, pp 3389-3398, 2012.

9.Zhe Yin, Nan Liu, Mingshu Ma, Lan Wang, Xing-Jie Liang, Yanli Hao*, Xiaoning Zhang*. A novel EGFR-targeted gene delivery system based on complexes self-assembled by EGF, DNA and activated PAMAM dendrimers, In J Nanomedicine 7, pp 4625-4635, 2012.

10.Nan Liu, Yanli Hao*, Zhe Yin, Mingshu Ma, Lan Wang, Xiaoning Zhang*. Self-Assembled Human Serum Albumin-Coated Complexes for Gene Delivery with Improved Transfection. Die Pharmazie, 67(2), pp 174-181, 2012/2.

11.Lan Wang, Yanli Hao*, Nan Liu, Zhe Yin, Mingshu Ma, Xiaoning Zhang*. Enhance the dissolution rate and oral bioavailability of pranlukast by preparing nanosuspensions with high-pressure homogenizing method. Drug Development and Industrial Pharmacy, 2012, 38(11):1381-1389