•Liu X*, Liu X*, Du Y*, …, David CJ, Sun Q, Chen M#.Aberrant accumulation of Kras-dependent enhancer RNAs and PROMPTs during tumor progression renders cancer cells susceptible to PAF1 depletion. Cell Reports. 2023 Aug 11;42(8)
•Chen M#. CircR-looping the leukemic translocations: The cause of MLL-translocations explained. Molecular Cell. 2023, Jul 6;83(13):2164-2166.
• Chen Q, Cevher MA, Jiang Q, Wang S , Sun XJ, Roeder RG#, Chen M#. LYL1 facilitates AETFC assembly and gene activation by recruiting CARM1 in t(8;21) AML. Proc Natl Acad Sci U S A.2022 Oct 18;119(42).
•Liu X, Guo Z, Han J；Peng B; Zhang B; Li H; Hu X; David CJ; Chen M#. The PAF1 complex promotes 3’ processing of pervasive transcripts. Cell Reports 2022 March 15, 38(11).
•Li Y, He Y., Peng J, Su Z, Li Z, Zhang B, Ma J, Zhuo M, Zou D, Liu X, Wang W, Huang D, Xu M, Wang J, Deng H, Xue J, Xie W, Lan X,Chen M, Zhao Y, Wu W and David CJ. Mutant Kras co-opts a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells to initiate pancreatic cancer. Nature Cancer. 2021 2: 49–65
•David CJ, Huang Y,Chen M, Su J, Zou Y, Bardeesy N, Iacobuzio-Donahue CA, Massagué J.TGF-β Tumor Suppression Through A Lethal EMT. Cell. 2016 Feb 25;164(5):1015-30.
•Zhu N,Chen M, Eng R, Sinha AU, Rahnamay NF, Koche R, Al-Shahrour F, Minehart JC, Chen CW, Deshpande AJ, Xu H, S. Chu H, Ebert BL, Roeder RG, Armstrong SA. Jmjd1c is required for MLL-AF9 and HOXA9 Mediated AML Stem Cell Self-Renewal. J Clin Invest. 2016 Mar 1;126(3):997-1011.
•Chen M, Zhu N, Liu X, Laurent B, Tang Z, Eng R, Shi Y, Armstrong SA, Roeder RG. JMJD1C is required for the survival of acute myeloid leukemia by functioning as a coactivator for key transcription factors. Genes Dev. 2015 Oct 15;29(20):2123-39.
•Chen M, David CJ, Manley JL(2012).Concentration-dependent control of pyruvate kinase M mutually exclusive splicing by hnRNP proteins.Nat Struct Mol Biol.19(3):346-54.
•David CJ#,Chen M#,Assanah M, Canoll P, Manley JL (2010) HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.Nature463: 364-8. * These authors contributed equally to this work.
•Chen M,Manley JL (2009). Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches.Nat Rev Mol Cell Biol.10(11):741-54.
•Feng Y,Chen M, Manley JL (2008). Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator.Nat Struct Mol Biol.15(10):1040-8.
