Medical sciences is currently one of the most active scientific fields in the world, with great potentials for major breakthroughs. ...[Detailed]
The group of Babak Javid recently published a paper titled ‘The essential mycobacterial amidotransferase GatCAB is a modulator of specific translational fidelity’ in Nature Microbiology in August, 2016. This work showed for the first time how GatCAB – an essential enzyme complex involved in the synthesis of glutamine and asparagine tRNAs regulates and modulates the fidelity of translation of glutamine and asparagine codons. Using a forward genetic selection and screen strategy, coupled with whole-genome sequencing they identified that mutations in gatA led to increased rates of mistranslation (specific errors in gene translation) of glutamine to glutamate and asparagine to aspartate. These mutant strains also showed increased phenotypic resistance to rifampicin – the most important antibiotic used for the treatment of tuberculosis.
Tsinghua University and Bristol-Myers Squibb Announce a Cooperation Agreement