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基础医学系

董晨

履历

    2017/02-至今              北京市”慢性疾病的免疫学研究”重点实验室, 主任

    2016/09- 至今             清华大学医学院院长

    2016/01-2016/09       清华大学医学院常务副院长

    2015- 至今                  北大 - 清华生命科学联合中心副主任(清华)

    2014- 至今                  清华大学免疫学研究所所长

    2013-2016                  清华大学医学院副院长

    2013- 至今                  清华大学医学院教授

    2010-2013                  美国德克萨斯大学安德森肿瘤中心讲席教授

    2008-2013                  美国德克萨斯大学安德森肿瘤中心炎症与肿瘤中心主任

    2008-2013                  美国德克萨斯大学安德森肿瘤中心免疫学系终身教授

    2004-2008                  美国德克萨斯大学安德森肿瘤中心免疫学系终身副教授

    2000-2004                  美国华盛顿大学(西雅图)免疫学系助理教授

    1997-2000                  美国耶鲁大学医学院免疫系博士后

    1990-1996                  美国阿拉巴马大学伯明翰分校细胞及分子生物学专业博士

    1985-1989                  中国武汉大学细胞生物学专业学士


研究领域与方向

董教授主要致力于免疫学的研究,重点探讨免疫耐受和免疫应答的分子调控机制, 以理解自身免疫和过敏疾病的发病机理, 并探索新型肿瘤免疫治疗。董晨教授是 Th17 细胞分化、调节和功能研究领域的奠基者和研究权威之一 , 并在 Tfh 和 Tfr 细胞的发现和研究中,做出了开创性贡献。他的主要研究领域包括:

1. T细胞分化和功能调控;

2. 细胞因子在炎症的功能及其机制;

3. 免疫耐受与肿瘤免疫治疗.


学术荣誉与奖励

    2019                    The 20th Wu Jieping- Paul Janssen Medical and Pharmaceutical Award

    2019                    Member, Chinese Academy of Sciences

    2019                    Wu Jieping Medicine Prize- Innovation Award in Medicine and Pharmacy

    2019                    Highly Cited Researcher, Web of Sciences

    2019                    International Cytokine and Interferon Society-BioLegend William E. Paul Award

    2019                    Dr. Tsai-Fan Yu Foundation Legacy Award, Society of Chinese Bioscientists in America

    2018                    Fountain Valley Investigator of Life Sciences (FViL)

    2018                    Highly Cited Researcher, Clarivate Analytics

    2017                    Highly Cited Researcher, Clarivate Analytics

    2016                    Highly Cited Researcher, Thomson Reuters

    2016                    Keynote speaker, 2016 Keystone Symposium on T Follicular Helper Cells and Germinal Centers

    2015                    Highly Cited Researcher, Thomson Reuters

    2014                    Highly Cited Researcher, Thomson Reuters

    2013                    Bayer Chair Professor, Tsinghua University

    2011                    Fellow, American Association for the Advancement of Science

    2009                    American Association of Immunologists-BD Biosciences Investigator Award

    2008                    Leukemia and Lymphoma Society Scholar Award

    2007                    American Lung Association Career Investigator Award

    2004                    Milstein Young Investigator award, International Society of Interferon and Cytokine Research

    2003                    Cancer Research Institute Investigator Award

    2002                    Young Investigator Award (1st Prize), International Cytokine Society

    2000                    Arthritis Investigator Award, Arthritis Foundation


关键词

Immunology and Inflammation

代表性论文

1.       Ni, L., Ye, F., Cheng, M.-L., Feng, Y., Deng, Y.-Q., Zhao, H., Wei, P., Ge, J., Gou, M., Li, X., Sun, L., Cao, T., Wang, P., Zhou, C., Zhang, R., Liang, P., Guo, H., Wang, X., Qin, C.-F., Chen, F. and Dong, C. Characterization of anti-viral immunity in recovered individuals infected by SARS-CoV-2. (2020) Immunity. In press.

 

2.       Wang, X., Ni, L., Wan, S., Zhao, X., Ding, X., Dejean, A. and Dong, C. Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells. (2020) Immunity. 52:328-341.

 

3.       Xu, W., Zhao, X., Wang, X., Feng, H., Gou, M., Jin, W., Wang, X., Liu, X. and Dong, C. The transcription factor Tox2 drives T follicular helper cell development via regulating chromatin accessibility. (2019) Immunity. 51:826-839

 

4.       Su, Y., Huang, J., Zhao, X., Lu, H., Wang, W., Yang, X. O., Shi, Y., Wang, X., Lai, Y. and Dong, C. (2019) Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation. (2019) Science Immunology. 4:36.

 

5.       Liu, X.,Wang, Y., Lu, H., Li, J., Yan, X., Xiao, M., Hao, J., Hoang, O. N., Khong, H., Chen, T., Huang, R., Wu, J., Zhao, Q., Wu, Q., Xu, S., Wang, X., Jin, W., Yu, S., Wang, Y., Wei, L., Wang, A., Zhong, B., Ni, L., Liu, X., Nurieva, R., Ye, L., Tian, Q., Bian, X.-W. and Dong, C. Genome-wide analysis identifies Nr4a1 as a key mediator of T cell dysfunction. (2019) Nature. 567:525-529.

 

6.       Xu, M., Lu, H., Wu, Y., Liu, K., Shi, Y., An, H., Zhang, J., Wang, X., Lai, Y. and Dong, C. An IL-25-mediated autoregulatory circuit in keratinocytes plays a pivotal role in psoriatic skin inflammation. (2018) Immunity. 48:787-798

 

7.       Li, J., Lee, Y., Li, Y., Jiang, Y., Lu, H., Zang, W., Zhao, X., Liu, L., Chen, Y., Tan, H., Yang, Z., Zhang, M. Q., Mak, T. W., Ni, L. and Dong, C. Co-inhibitory molecule B7 superfamily member 1 expressed by tumor-infiltrating myeloid cells induces dysfunction of anti-tumor CD8+ T cells. (2018) Immunity. 48:773-786

 

8.       Jiang, Y., Liu, Y., Lu, H., Sun, S.-C., Jin, W., Wang, X. and Dong, C. Epigenetic activation during T helper 17 (Th17) cell differentiation is mediated by Tripartite motif containing 28. (2018) Nature Communications. 9:1424.

 

9.       Fu, W., Liu, X., Lin, X., Feng, H., Sun, L., Li, S., Chen, H., Tang, H., Lu, L., Jin, W. and Dong, C. Deficiency in T follicular regulatory cells promotes autoimmunity. (2018) Journal of Experimental Medicine. 215:815-825.


联系方式

Email: chendong at tsinghua.edu.cn

Phone: +86-10-62798095

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