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生物医学工程系

程京

履历

    2000- 至今      清华大学医学院生物医学工程系    教授

    2000- 至今      生物芯片北京国家工程研究中心    主任

    2000- 至今      博奥生物集团有限公司                  总裁

    1999-2000      清华大学生物科学与技术系           教授、博士生导师

    1996-2000      Pennsylvania 大学医学院             研究助理教授

                            美国 Nanogen 公司                    资深科学家暨工程师

                                                                               首席研究员

                            美国 AVIVA 公司                         技术总监

    1994-1996      美国 Pennsylvania 大学               博士后

    1993-1994      美国 Aberdeen 大学                    博士后

    1992-1993      英国 Strathclyde 大学                  博士后

    1989-1992      英国 Strathclyde 大学司法生物学博士

    1986-1999      西南政法大学法鉴定中心助理工程师、研究员

    1983-1986      铁道部资阳内燃机车厂柴油机分厂助理工程师

    1979-1983     上海铁道大学(现同济大学)电气工程系 , 工学士


研究领域与方向

主要从事 DNA 芯片、蛋白芯片、细胞芯片和芯片缩微实验室的研究开发和在健康管理、疾病诊断、 食品安全检测、药物开发中的应用研究,以及依托互联网大数据和人工智能的大健康管理相关研究。


1.  The design and development of biochips: Develop novel biochips including microarrays, microfluidics chips and lab-on-a-chip devices for mutation detection, gene expression, protein analysis, cell assay, etc.

2.  Translational study in using chips for personalized medicine: Emphasize application of biochips for personalized medical applications in oncology, inherited diseases, infectious diseases, reproductive medicine etc.

3.  The study of new detection methods: Interested in developing new labeling and labelless detection technologies.

学术荣誉与奖励

    国家杰出青年基金获得者

关键词

Medical Biophysics

代表性论文

1.     Meng, X., Zhu, Y., Chen, Y., Lu, Y., Xu, Y. and Cheng, J. "Conditional siphon priming for multi-step assays on centrifugalmicrofluidic platforms"
Sensors and Actuators B: Chemical, 2017, 242: 710-717

2.     Xu, Y., Xie, X., Duan, Y., Wang, L., Cheng, Z. and Cheng, J. (2016)“A review of impedance measurements of whole cells”

Biosensors and Bioelectronics, 2016, 77: 824-836

3.     Xie, X., Liu, R., X,u Y., Wang, L., Lan, Z., Chen, W., Liu, H., Lu, Y., Cheng, J. "In vitro hyperthermia studied in a continuous manner using electric impedance sensing"
RSC Advances, 2015, 5(76):62007-62016

4.     Liu,W., Chen,W., Liu, ., Ou,Y., Liu, H., Xie,L., Lu,Y., Li,C., Li,B., Cheng,J."Separation of sperm and epithelial cells based on the hydrodynamic effect for forensic analysis"
Biofluidics, 2015, 9(4):044127

5.     Li, Z., Liu, W., Qiu, T., Xie, L., Chen, W., Liu, R., Lu, Y., Mitchelson, K., Wang, J., Qiao, J. Cheng, J."The construction of an interfacial valve-based microfluidic chip for thermotaxis evaluation of human sperm"
Biomicrofluidics, 2014, 8:024102

6.     Qin, W., Dong, P., Ma, C., Mitchelson, K., Deng, T., Zhang, L., Sun, Y., Feng, X., Ding, Y., Lu, X., He, J., Wen, H. and Cheng, J. MicroRNA-133b is a key promoter of cervical carcinoma development through the activation of the ERK and AKT1 pathways. Onc ogene, 2012, 31: 4067–4075.

7.     Cheng, J.Biochips for translational medicine. Science, Selected Presentations from the 2011 Sino-American Symposium on Clinical and Translational Medicine, S. Sanders Ed. (Science/AAAS, Washington, DC, 2011): 68.

8.     Guo, H., Liu, H., Mitchelson, K., Rao, H., Luo, M., Xie, L., Sun, Y., Zhang, L., Lu, Ying., Liu, R., Ren, A., Liu, S., Zhou, S., Zhu, J., Zhou, Y., Huang, A., Wei, L., Guo, Y. and Cheng, J. MicroRNAs-372/373 promote the expression of hepatitis B virus through the targeting of nuclear factor I/B. Hepetology, 2011, 54 (3): 808–819.

9.     Xie, L., Ma, R., Han, C., Su, K., Zhang, Q., Qiu, T., Wang, L., Huang, G., Qiao, J., Wang, J. and Cheng, J. Integration of sperm motility and chemotaxis screening with a microchannel-based device. Clinical Chemistry, 2010, 56(8): 1270-1278.

10.   Wang, L., Zhu, J., Deng C., Xing W. and Cheng, J. An automatic and quantitative on-chip cell migration assay using self-assembled monolayers combined with real-time cellular impedance sensing. Lab on a Chip, 2008, 8(6): 872-878. (Cover)

11.   Li, C., Pan, Q., Guo, Y., Li, Y., Gao, H., Zhang, D., Hu, H., Xing, W., Mitchelson, K., Xia, K., Dai, P. and Cheng, J. Construction of a multiplex all ele-specific PCR-based universal array (ASPUA) and its application to hearing loss screening. Human Mutation, 2008, 29(2): 306-314.

12.   Qiao, J., Shao, W., Wei, H., Sun, Y., Zhao, Y., Xing, W., Zhang, L., Mitchelson, K. and Cheng, J. Novel high-throughput profiling of human transcription factors and its use for systematic pathway mapping. Journal of Proteome Research, 2008, 7(7): 2769-2779.

13.   Shi, L., Reid, L.H., Jones, W.D., Shippy, R., Warrington, J.A., Baker, S.C., Collins, P.J., de Longueville, F., Kawasaki, E.S., Lee, K.Y., Luo, Y., Sun, Y.A., Willey, J.C., Setterquist, R.A., Fischer, G.M., Tong, W., Dragan, Y.P., Dix, D.J., Frueh, F.W., Goodsaid, F.M., Herman, D., Jensen, R.V., Johnson, C.D., Lobenhofer, E.K., Puri, R.K., Scherf, U., Thierry-M ieg, J., Wang, C., Wilson, M., Wolber, P.K., Zhang, L., Amur, S., Bao, W., Barbacioru, C.C., Lucas, A.B., Bertholet, V., Boysen, C., Bromley, B., Brown, D., Brunner, A., Canales, R., Cao, X.M., Cebula, T.A., Chen, J.J., Cheng, J., et al. The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression me asurements. Nature Biotechnology, 2006, 24(9): 1151-1161.

14.   Cheng, J., Sheldon, E.L., Wu, L., Uribe, A., Gerrue, L.O., Carrino J., Heller, M.J., Carrino, J. and OConnell, J.P. Preparation and hybridization analysis of DNA/RNA from E. coli on microfabricated bioelectronic chips. Nature Biotechnology, 1998, 16(6): 541-546. (Cover)

15.   Cheng,J. and Kricka, L.J. (eds.) Biochip Technology. Harwood Academic Publishers, Pennsylvania, U.S.A.,2001.


联系方式

Email: jcheng at tsinghua.edu.cn

Phone: +86-10-62772239

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